ethyl 3-(5-(3-fluoro-4-(5-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)phenyl)pyrimidin-2-yloxy)cyclobutanecarboxylate

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Chemical Name:ethyl 3-(5-(3-fluoro-4-(5-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)phenyl)pyrimidin-2-yloxy)cyclobutanecarboxylate
CAS No.:1438250-35-1
Molecular Formula:C₂₅H₂₀F₄N₄O₃
Molecular Weight:500.452
Hs Code.:

Synonyms:ethyl 3-(5-(3-fluoro-4-(5-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)phenyl)pyrimidin-2-yloxy)cyclobutanecarboxylate

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Chemical Property of ethyl 3-(5-(3-fluoro-4-(5-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)phenyl)pyrimidin-2-yloxy)cyclobutanecarboxylate

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Technology Process of ethyl 3-(5-(3-fluoro-4-(5-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)phenyl)pyrimidin-2-yloxy)cyclobutanecarboxylate

There total 5 articles about ethyl 3-(5-(3-fluoro-4-(5-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)phenyl)pyrimidin-2-yloxy)cyclobutanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1370534-66-9
2-(2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-5-(trifluoromethyl)-1H-benzo[d]imidazole?

: 1438249-75-2
ethyl 3-(5-bromopyrimidin-2-yloxy)cyclobutanecarboxylate

: 1438250-35-1
ethyl 3-(5-(3-fluoro-4-(5-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)phenyl)pyrimidin-2-yloxy)cyclobutanecarboxylate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In methanol; 1,2-dimethoxyethane; at 120 ℃; for 0.333333h; Inert atmosphere; Microwave irradiation;

Reference yield:

: 368-71-8
4-(trifluoromethyl)-1,2-phenylenediamine

: 1438250-35-1
ethyl 3-(5-(3-fluoro-4-(5-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)phenyl)pyrimidin-2-yloxy)cyclobutanecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: Oxone / water; N,N-dimethyl-formamide / 1.5 h / 20 °C

2: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / dimethyl sulfoxide / 18 h / 100 °C

3: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; methanol / 0.33 h / 120 °C / Inert atmosphere; Microwave irradiation

With Oxone; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; sodium carbonate; In methanol; 1,2-dimethoxyethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 57848-46-1
4-bromo-2-fluorobenzaldehyde

: 1438250-35-1
ethyl 3-(5-(3-fluoro-4-(5-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)phenyl)pyrimidin-2-yloxy)cyclobutanecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: Oxone / water; N,N-dimethyl-formamide / 1.5 h / 20 °C

2: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / dimethyl sulfoxide / 18 h / 100 °C

3: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; methanol / 0.33 h / 120 °C / Inert atmosphere; Microwave irradiation

With Oxone; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; sodium carbonate; In methanol; 1,2-dimethoxyethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;