3-(5-(3-fluoro-4-(5-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)phenyl)pyrimidin-2-yloxy)cyclobutanecarboxylic acid

Base Information

Chemical Name:3-(5-(3-fluoro-4-(5-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)phenyl)pyrimidin-2-yloxy)cyclobutanecarboxylic acid
CAS No.:1438244-63-3
Molecular Formula:C₂₃H₁₆F₄N₄O₃
Molecular Weight:472.399
Hs Code.:

Synonyms:3-(5-(3-fluoro-4-(5-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)phenyl)pyrimidin-2-yloxy)cyclobutanecarboxylic acid

Suppliers and Price of 3-(5-(3-fluoro-4-(5-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)phenyl)pyrimidin-2-yloxy)cyclobutanecarboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-(5-(3-fluoro-4-(5-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)phenyl)pyrimidin-2-yloxy)cyclobutanecarboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-(5-(3-fluoro-4-(5-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)phenyl)pyrimidin-2-yloxy)cyclobutanecarboxylic acid

There total 7 articles about 3-(5-(3-fluoro-4-(5-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)phenyl)pyrimidin-2-yloxy)cyclobutanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1438250-35-1
ethyl 3-(5-(3-fluoro-4-(5-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)phenyl)pyrimidin-2-yloxy)cyclobutanecarboxylate

: 1438244-63-3
3-(5-(3-fluoro-4-(5-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)phenyl)pyrimidin-2-yloxy)cyclobutanecarboxylic acid

Guidance literature:: ethyl 3-(5-(3-fluoro-4-(5-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)phenyl)pyrimidin-2-yloxy)cyclobutanecarboxylate; With water; lithium hydroxide; In tetrahydrofuran; methanol; at 80 ℃; for 0.333333h;

With hydrogenchloride; In tetrahydrofuran; methanol; water; pH=4;

Reference yield:

: 57848-46-1
4-bromo-2-fluorobenzaldehyde

: 1438244-63-3
3-(5-(3-fluoro-4-(5-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)phenyl)pyrimidin-2-yloxy)cyclobutanecarboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: Oxone / water; N,N-dimethyl-formamide / 1.5 h / 20 °C

2.1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / dimethyl sulfoxide / 18 h / 100 °C

3.1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; methanol / 0.33 h / 120 °C / Inert atmosphere; Microwave irradiation

4.1: lithium hydroxide; water / tetrahydrofuran; methanol / 0.33 h / 80 °C

4.2: pH 4

With Oxone; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; water; potassium acetate; sodium carbonate; lithium hydroxide; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 368-71-8
4-(trifluoromethyl)-1,2-phenylenediamine

: 1438244-63-3
3-(5-(3-fluoro-4-(5-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)phenyl)pyrimidin-2-yloxy)cyclobutanecarboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: Oxone / water; N,N-dimethyl-formamide / 1.5 h / 20 °C

2.1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / dimethyl sulfoxide / 18 h / 100 °C

3.1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; methanol / 0.33 h / 120 °C / Inert atmosphere; Microwave irradiation

4.1: lithium hydroxide; water / tetrahydrofuran; methanol / 0.33 h / 80 °C

4.2: pH 4

With Oxone; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; water; potassium acetate; sodium carbonate; lithium hydroxide; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;