(2R)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-1,2,3,4-tetrazol-1-yl)-1-{5-[4-(2,2,2-trifluoroethoxy)phenyl]pyridin-2-yl}propan-2-ol

Base Information

Chemical Name:(2R)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-1,2,3,4-tetrazol-1-yl)-1-{5-[4-(2,2,2-trifluoroethoxy)phenyl]pyridin-2-yl}propan-2-ol
CAS No.:1340593-59-0
Molecular Formula:C₂₃H₁₆F₇N₅O₂
Molecular Weight:527.401
Hs Code.:

Synonyms:(2R)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-1,2,3,4-tetrazol-1-yl)-1-{5-[4-(2,2,2-trifluoroethoxy)phenyl]pyridin-2-yl}propan-2-ol

Suppliers and Price of (2R)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-1,2,3,4-tetrazol-1-yl)-1-{5-[4-(2,2,2-trifluoroethoxy)phenyl]pyridin-2-yl}propan-2-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

ChemScene
Oteseconazole 99.56%
50mg
$ 1650.00

ChemScene
Oteseconazole 99.56%
25mg
$ 990.00

ChemScene
Oteseconazole 99.56%
10mg
$ 550.00

ChemScene
Oteseconazole 99.56%
5mg
$ 350.00

Total 16 raw suppliers

Chemical Property of (2R)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-1,2,3,4-tetrazol-1-yl)-1-{5-[4-(2,2,2-trifluoroethoxy)phenyl]pyridin-2-yl}propan-2-ol

Chemical Property:

Boiling Point:609.2±65.0 °C(Predicted)
Density:1.47±0.1 g/cm3(Predicted)

Purity/Quality:

99%, ^*data from raw suppliers

Oteseconazole 99.56% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2R)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-1,2,3,4-tetrazol-1-yl)-1-{5-[4-(2,2,2-trifluoroethoxy)phenyl]pyridin-2-yl}propan-2-ol

There total 38 articles about (2R)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-1,2,3,4-tetrazol-1-yl)-1-{5-[4-(2,2,2-trifluoroethoxy)phenyl]pyridin-2-yl}propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 294181-95-6
2-(5-bromopyridine-2-yl)-2,2-difluoroacetic acid ethyl ester

: 1340593-59-0
(2R)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-1,2,3,4-tetrazol-1-yl)-1-{5-[4-(2,2,2-trifluoroethoxy)phenyl]pyridin-2-yl}propan-2-ol

Guidance literature:: Multi-step reaction with 5 steps

1: n-butyllithium / tert-butyl methyl ether / -65 °C

2: potassium carbonate / ethanol

3: lithium aluminium tetrahydride

4: potassium carbonate; palladium bis[bis(diphenylphosphino)ferrocene] dichloride / water; iso-butanol

5: sodium azide

With lithium aluminium tetrahydride; n-butyllithium; sodium azide; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium carbonate; In ethanol; tert-butyl methyl ether; water; iso-butanol; 2: |Henry Nitro Aldol Condensation;
DOI:10.1358/dof.2019.44.11.3035583

Reference yield:

: 294182-06-2
2-(5-bromopyridin-2-yl)-1-(2,4-difluorophenyl)-2,2-difluoroethanone

: 1340593-59-0
(2R)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-1,2,3,4-tetrazol-1-yl)-1-{5-[4-(2,2,2-trifluoroethoxy)phenyl]pyridin-2-yl}propan-2-ol

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / ethanol

2: lithium aluminium tetrahydride

3: potassium carbonate; palladium bis[bis(diphenylphosphino)ferrocene] dichloride / water; iso-butanol

4: sodium azide

With lithium aluminium tetrahydride; sodium azide; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium carbonate; In ethanol; water; iso-butanol; 1: |Henry Nitro Aldol Condensation;
DOI:10.1358/dof.2019.44.11.3035583

Reference yield:

: 624-28-2
2,5-dibromopyridine

: 1340593-59-0,1340593-77-2
2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)-1-(5-(4-(2,2,2-trifluoroethoxy)phenyl)pyridin-2-yl)propan-2-ol

Guidance literature:: Multi-step reaction with 5 steps

1: copper / dimethyl sulfoxide

2: n-butyllithium / tert-butyl methyl ether / -65 °C

3: potassium tert-butylate / diethyl ether

4: potassium carbonate; palladium bis[bis(diphenylphosphino)ferrocene] dichloride / tetrahydrofuran; water / 75 °C

5: potassium carbonate / N,N-dimethyl-formamide / 70 °C

With n-butyllithium; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium tert-butylate; copper; potassium carbonate; In tetrahydrofuran; diethyl ether; tert-butyl methyl ether; water; dimethyl sulfoxide; N,N-dimethyl-formamide; 1: |Ullmann Condensation / 4: |Suzuki Coupling;
DOI:10.1358/dof.2019.44.11.3035583