8-<(2'-cyanobiphenyl-4-yl)methyl>-5-methyl-7-n-propyl-<1,2,4>-triazolo<1,5-c>pyrimidine-2-sulfonyl chloride

Base Information

Chemical Name:8-<(2'-cyanobiphenyl-4-yl)methyl>-5-methyl-7-n-propyl-<1,2,4>-triazolo<1,5-c>pyrimidine-2-sulfonyl chloride
CAS No.:148474-70-8
Molecular Formula:C₂₃H₂₀ClN₅O₂S
Molecular Weight:465.963
Hs Code.:

Synonyms:8-<(2'-cyanobiphenyl-4-yl)methyl>-5-methyl-7-n-propyl-<1,2,4>-triazolo<1,5-c>pyrimidine-2-sulfonyl chloride

Suppliers and Price of 8-<(2'-cyanobiphenyl-4-yl)methyl>-5-methyl-7-n-propyl-<1,2,4>-triazolo<1,5-c>pyrimidine-2-sulfonyl chloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 8-<(2'-cyanobiphenyl-4-yl)methyl>-5-methyl-7-n-propyl-<1,2,4>-triazolo<1,5-c>pyrimidine-2-sulfonyl chloride

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 8-<(2'-cyanobiphenyl-4-yl)methyl>-5-methyl-7-n-propyl-<1,2,4>-triazolo<1,5-c>pyrimidine-2-sulfonyl chloride

There total 7 articles about 8-<(2'-cyanobiphenyl-4-yl)methyl>-5-methyl-7-n-propyl-<1,2,4>-triazolo<1,5-c>pyrimidine-2-sulfonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 148474-66-2
8-<(2'-cyanobiphenyl-4-yl)methyl>-2-mercapto-5-methyl-7-n-propyl-<1,2,4>-triazolo<1,5-c>pyrimidine

: 148474-70-8
8-<(2'-cyanobiphenyl-4-yl)methyl>-5-methyl-7-n-propyl-<1,2,4>-triazolo<1,5-c>pyrimidine-2-sulfonyl chloride

Guidance literature:: With hydrogenchloride; sodium chlorate; In water; at 0 ℃; for 0.333333h;
DOI:10.1021/jm00041a016

Reference yield:

: 114772-54-2
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile

: 148474-70-8
8-<(2'-cyanobiphenyl-4-yl)methyl>-5-methyl-7-n-propyl-<1,2,4>-triazolo<1,5-c>pyrimidine-2-sulfonyl chloride

Guidance literature:: Multi-step reaction with 6 steps

1: (i-Pr)2NEt, LiCl / tetrahydrofuran / 15 h / Heating

2: 1.) MeONa / 1.) MeOH, RT, 15 min, 2.) MeOH, a) RT, 20 h, b) reflux, 3 h

3: 98 percent / POCl₃ / 6 h / 100 °C

4: 92 percent / N₂H₄ / ethanol / 2 h / Heating

5: 86 percent / butan-1-ol / 3 h / Heating

6: 8 g / NaClO₃, conc. HCl / H₂O / 0.33 h / 0 °C

With hydrogenchloride; sodium chlorate; sodium methylate; N-ethyl-N,N-diisopropylamine; lithium chloride; hydrazine; trichlorophosphate; In tetrahydrofuran; ethanol; water; butan-1-ol;
DOI:10.1021/jm00041a016

Reference yield:

: 3249-68-1
ethyl butyroyl acetate

: 148474-70-8
8-<(2'-cyanobiphenyl-4-yl)methyl>-5-methyl-7-n-propyl-<1,2,4>-triazolo<1,5-c>pyrimidine-2-sulfonyl chloride

Guidance literature:: Multi-step reaction with 6 steps

1: (i-Pr)2NEt, LiCl / tetrahydrofuran / 15 h / Heating

2: 1.) MeONa / 1.) MeOH, RT, 15 min, 2.) MeOH, a) RT, 20 h, b) reflux, 3 h

3: 98 percent / POCl₃ / 6 h / 100 °C

4: 92 percent / N₂H₄ / ethanol / 2 h / Heating

5: 86 percent / butan-1-ol / 3 h / Heating

6: 8 g / NaClO₃, conc. HCl / H₂O / 0.33 h / 0 °C

With hydrogenchloride; sodium chlorate; sodium methylate; N-ethyl-N,N-diisopropylamine; lithium chloride; hydrazine; trichlorophosphate; In tetrahydrofuran; ethanol; water; butan-1-ol;
DOI:10.1021/jm00041a016