(R)-4-Amino-1-({4-[((R)-4-amino-2-hydroxy-butyl)-benzyl-amino]-butyl}-benzyl-amino)-butan-2-ol

Base Information

Chemical Name:(R)-4-Amino-1-({4-[((R)-4-amino-2-hydroxy-butyl)-benzyl-amino]-butyl}-benzyl-amino)-butan-2-ol
CAS No.:177797-99-8
Molecular Formula:C₂₆H₄₂N₄O₂
Molecular Weight:442.645
Hs Code.:

Synonyms:(R)-4-Amino-1-({4-[((R)-4-amino-2-hydroxy-butyl)-benzyl-amino]-butyl}-benzyl-amino)-butan-2-ol

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Chemical Property of (R)-4-Amino-1-({4-[((R)-4-amino-2-hydroxy-butyl)-benzyl-amino]-butyl}-benzyl-amino)-butan-2-ol

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Technology Process of (R)-4-Amino-1-({4-[((R)-4-amino-2-hydroxy-butyl)-benzyl-amino]-butyl}-benzyl-amino)-butan-2-ol

There total 3 articles about (R)-4-Amino-1-({4-[((R)-4-amino-2-hydroxy-butyl)-benzyl-amino]-butyl}-benzyl-amino)-butan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 177797-98-7
4,9-dibenzyl-1,12-dicyano-(2R),(11R)-dihydroxy-4,9-diazadodecane

: 177797-99-8
(R)-4-Amino-1-({4-[((R)-4-amino-2-hydroxy-butyl)-benzyl-amino]-butyl}-benzyl-amino)-butan-2-ol

Guidance literature:: With ammonia; hydrogen; nickel; In methanol; for 7h; under 2585.7 Torr;
DOI:10.1021/jm950827h

Reference yield:

: 31719-05-8
N,N'-dibenzylbutane-1,4-diamine

: 177797-99-8
(R)-4-Amino-1-({4-[((R)-4-amino-2-hydroxy-butyl)-benzyl-amino]-butyl}-benzyl-amino)-butan-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 68 percent / MgSO₄ / methanol / 48 h / Ambient temperature

2: 65 percent / 18-crown-6 / acetonitrile / 48 h / 60 °C

3: 86 percent / H₂, NH₃ / Raney Ni / methanol / 7 h / 2585.7 Torr

With 18-crown-6 ether; ammonia; hydrogen; magnesium sulfate; nickel; In methanol; acetonitrile;
DOI:10.1021/jm950827h

Reference yield:

: 177797-97-6
4,9-dibenzyl-1,12-dichloro-(2S),(11S)-dihydroxy-4,9-diazadodecane

: 177797-99-8
(R)-4-Amino-1-({4-[((R)-4-amino-2-hydroxy-butyl)-benzyl-amino]-butyl}-benzyl-amino)-butan-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 65 percent / 18-crown-6 / acetonitrile / 48 h / 60 °C

2: 86 percent / H₂, NH₃ / Raney Ni / methanol / 7 h / 2585.7 Torr

With 18-crown-6 ether; ammonia; hydrogen; nickel; In methanol; acetonitrile;
DOI:10.1021/jm950827h