177797-97-6Relevant articles and documents
Metabolically programmed polyamine analogue antidiarrheals
Bergeron, Raymond J.,Yao, Guo Wei,Yao, Hua,Weimar, William R.,Sninsky, Charles A.,Raisler, Brian,Feng, Yang,Wu, Qianhong,Gao, Fenglan
, p. 2461 - 2471 (1996)
The design, synthesis, and testing of a novel class of antidiarrheal drugs based on a tetraamine pharmacophore are reported. While N1,N14- diethylhomospermine (DEHSPM) (5 mg/kg) completely prevents diarrhea in rodents, tissue distrib