4-(7-(ethylamino)-6-nitro-4-quinazolinyl)-1-piperazinecarboxylic acid tert-butyl ester

Base Information

Chemical Name:4-(7-(ethylamino)-6-nitro-4-quinazolinyl)-1-piperazinecarboxylic acid tert-butyl ester
CAS No.:205259-33-2
Molecular Formula:C₁₉H₂₆N₆O₄
Molecular Weight:402.453
Hs Code.:

Synonyms:4-(7-(ethylamino)-6-nitro-4-quinazolinyl)-1-piperazinecarboxylic acid tert-butyl ester

Suppliers and Price of 4-(7-(ethylamino)-6-nitro-4-quinazolinyl)-1-piperazinecarboxylic acid tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-(7-(ethylamino)-6-nitro-4-quinazolinyl)-1-piperazinecarboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-(7-(ethylamino)-6-nitro-4-quinazolinyl)-1-piperazinecarboxylic acid tert-butyl ester

There total 1 articles about 4-(7-(ethylamino)-6-nitro-4-quinazolinyl)-1-piperazinecarboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 53449-14-2
7-chloro-6-nitro-4(3H)-quinazolinone

: 205259-33-2
4-(7-(ethylamino)-6-nitro-4-quinazolinyl)-1-piperazinecarboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: dimethylsulfoxide / 180 °C

2: POCl₃ / Heating

3: propan-2-ol / 4 h / Heating

4: 92 percent / Et₃N / CH₂Cl₂ / 20 °C

With triethylamine; trichlorophosphate; In dichloromethane; dimethyl sulfoxide; isopropyl alcohol;
DOI:10.1021/jm020505v

Reference yield:

: 205259-33-2
4-(7-(ethylamino)-6-nitro-4-quinazolinyl)-1-piperazinecarboxylic acid tert-butyl ester

: N-Benzyl-4-(1,3-dihydro-3-ethyl-1-methyl-2-oxo-2H-imidazo[4,5-g]quinazolin-8-yl)-1-piperazinethiocarboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: H₂ / Pd/C / ethanol; H₂O / 6 h / 20 °C

2.1: 100 percent / Et₃N / dimethylformamide / 4.5 h / 80 °C

3.1: NaH / dimethylformamide / 0.5 h / 20 °C

3.2: 51 percent / dimethylformamide / 20 °C

4.1: CF₃COOH / CH₂Cl₂ / 1.5 h / cooling

5.1: Et₃N / dimethylformamide / 20 °C

With hydrogen; sodium hydride; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm020505v

Reference yield:

: 205259-33-2
4-(7-(ethylamino)-6-nitro-4-quinazolinyl)-1-piperazinecarboxylic acid tert-butyl ester

: 4-(1,3-Dihydro-3-ethyl-1-methyl-2-oxo-2H-imidazo[4,5-g]quinazolin-8-yl)-N-(4-phenoxyphenyl)-1-piperazinecarboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: H₂ / Pd/C / ethanol; H₂O / 6 h / 20 °C

2.1: 100 percent / Et₃N / dimethylformamide / 4.5 h / 80 °C

3.1: NaH / dimethylformamide / 0.5 h / 20 °C

3.2: 51 percent / dimethylformamide / 20 °C

4.1: CF₃COOH / CH₂Cl₂ / 1.5 h / cooling

5.1: Et₃N / dimethylformamide / 20 °C

With hydrogen; sodium hydride; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm020505v