(2R,5S)-2-dodecanoyl-3-phenyl-1,3-diazabicyclo[3.3.0]-octane

Base Information

• Chemical Name: (2R,5S)-2-dodecanoyl-3-phenyl-1,3-diazabicyclo[3.3.0]-octane
• CAS No.: 959781-09-0
• Molecular Formula: C₂₄H₃₈N₂O
• Molecular Weight: 370.579
• Mol file: 959781-09-0.mol

Synonyms:(2R,5S)-2-dodecanoyl-3-phenyl-1,3-diazabicyclo[3.3.0]-octane

Chemical Property of (2R,5S)-2-dodecanoyl-3-phenyl-1,3-diazabicyclo[3.3.0]-octane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,5S)-2-dodecanoyl-3-phenyl-1,3-diazabicyclo[3.3.0]-octane

There total 2 articles about (2R,5S)-2-dodecanoyl-3-phenyl-1,3-diazabicyclo[3.3.0]-octane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

bromoundecane (693-67-4) + 2-Methoxycarbonyl-3-phenyl-1,3-diazabicyclo<3.3.0>octane (165879-49-2) → (2R,5S)-2-dodecanoyl-3-phenyl-1,3-diazabicyclo[3.3.0]-octane (959781-09-0)

Guidance literature:

bromoundecane; With iodine; magnesium; In diethyl ether;

2-Methoxycarbonyl-3-phenyl-1,3-diazabicyclo<3.3.0>octane; In tetrahydrofuran; diethyl ether; at -100 ℃; for 0.333333h; Further stages.;

DOI:10.1016/j.tetasy.2007.09.012

Reference yield:

(2S)-2-(anilinomethyl)pyrrolidine (64030-44-0) → (2R,5S)-2-dodecanoyl-3-phenyl-1,3-diazabicyclo[3.3.0]-octane (959781-09-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 98 percent / benzene / 1 h / Heating

2.1: magnesium; iodine / diethyl ether

2.2: 79 percent / diethyl ether; tetrahydrofuran / 0.33 h / -100 °C

With iodine; magnesium; In diethyl ether; benzene; 2.2: Grignard reaction;

DOI:10.1016/j.tetasy.2007.09.012

Reference yield:

(2R,5S)-2-dodecanoyl-3-phenyl-1,3-diazabicyclo[3.3.0]-octane (959781-09-0) + trimethyl ortho-4-bromobutanoate (55444-67-2) → C31H54N2O4

Guidance literature:

trimethyl ortho-4-bromobutanoate; With iodine; magnesium; In tetrahydrofuran;

(2R,5S)-2-dodecanoyl-3-phenyl-1,3-diazabicyclo[3.3.0]-octane; In tetrahydrofuran; at -78 - 20 ℃; for 17h; Further stages.;

DOI:10.1016/j.tetasy.2007.09.012

upstream raw materials:

bromoundecane

2-Methoxycarbonyl-3-phenyl-1,3-diazabicyclo<3.3.0>octane

(2S)-2-(anilinomethyl)pyrrolidine