N-(2-aminoethyl)-N-{1-[4-cyano-5-methyl-6-oxo-1-(phenylmethyl)-1,6-dihydro-2-pyrimidinyl]-2-methylpropyl}-2-propenamide

Base Information

• Chemical Name: N-(2-aminoethyl)-N-{1-[4-cyano-5-methyl-6-oxo-1-(phenylmethyl)-1,6-dihydro-2-pyrimidinyl]-2-methylpropyl}-2-propenamide
• CAS No.: 1044661-23-5
• Molecular Formula: C₂₂H₂₇N₅O₂
• Molecular Weight: 393.489
• Mol file: 1044661-23-5.mol

Synonyms:N-(2-aminoethyl)-N-{1-[4-cyano-5-methyl-6-oxo-1-(phenylmethyl)-1,6-dihydro-2-pyrimidinyl]-2-methylpropyl}-2-propenamide

Chemical Property of N-(2-aminoethyl)-N-{1-[4-cyano-5-methyl-6-oxo-1-(phenylmethyl)-1,6-dihydro-2-pyrimidinyl]-2-methylpropyl}-2-propenamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-aminoethyl)-N-{1-[4-cyano-5-methyl-6-oxo-1-(phenylmethyl)-1,6-dihydro-2-pyrimidinyl]-2-methylpropyl}-2-propenamide

There total 9 articles about N-(2-aminoethyl)-N-{1-[4-cyano-5-methyl-6-oxo-1-(phenylmethyl)-1,6-dihydro-2-pyrimidinyl]-2-methylpropyl}-2-propenamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,1-dimethylethyl [2-(acryloyl{1-[4-cyano-5-methyl-6-oxo-1-(phenylmethyl)-1,6-dihydro-2-pyrimidinyl]-2-methylpropyl}amino)ethyl]carbamate (1044661-22-4) → N-(2-aminoethyl)-N-{1-[4-cyano-5-methyl-6-oxo-1-(phenylmethyl)-1,6-dihydro-2-pyrimidinyl]-2-methylpropyl}-2-propenamide (1044661-23-5)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

[1-(3-benzyl-5-methyl-6-hydroxy-4-oxo-3,4-dihydro-pyrimidin-2-yl)-2-methyl-propyl]-carbamic acid t-butyl ester (625840-40-6) → N-(2-aminoethyl)-N-{1-[4-cyano-5-methyl-6-oxo-1-(phenylmethyl)-1,6-dihydro-2-pyrimidinyl]-2-methylpropyl}-2-propenamide (1044661-23-5)

Guidance literature:

Multi-step reaction with 6 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 20 °C

1.2: 18 h / 20 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 4 h / 90 °C

3.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

4.1: sodium tris(acetoxy)borohydride / dichloromethane / 20 °C

5.1: triethylamine / dichloromethane / 20 °C

6.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With sodium tris(acetoxy)borohydride; sodium hydride; triethylamine; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

C22H28F3N3O6S (851635-08-0) → N-(2-aminoethyl)-N-{1-[4-cyano-5-methyl-6-oxo-1-(phenylmethyl)-1,6-dihydro-2-pyrimidinyl]-2-methylpropyl}-2-propenamide (1044661-23-5)

Guidance literature:

Multi-step reaction with 5 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 4 h / 90 °C

2: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

3: sodium tris(acetoxy)borohydride / dichloromethane / 20 °C

4: triethylamine / dichloromethane / 20 °C

5: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With sodium tris(acetoxy)borohydride; triethylamine; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

1,1-dimethylethyl [2-(acryloyl{1-[4-cyano-5-methyl-6-oxo-1-(phenylmethyl)-1,6-dihydro-2-pyrimidinyl]-2-methylpropyl}amino)ethyl]carbamate

2-(1-amino-2-methylpropyl)-5-methyl-6-oxo-1-(phenylmethyl)-1,6-dihydro-4-pyrimidinecarbonitrile

[(R)-1-(N-benzyl-carbamimidoyl)-2-methyl-propyl]-carbamic acid t-butyl ester

[1-(3-benzyl-5-methyl-6-hydroxy-4-oxo-3,4-dihydro-pyrimidin-2-yl)-2-methyl-propyl]-carbamic acid t-butyl ester

Downstream raw materials:

5-methyl-2-[2-methyl-1-(7-oxohexahydro-1H-1,4-diazepin-1-yl)propyl]-6-oxo-1-(phenylmethyl)-1,6-dihydro-4-pyrimidinecarbonitrile