benzyl 2,2-difluoro-2-phenylacetate

Base Information

• Chemical Name: benzyl 2,2-difluoro-2-phenylacetate
• CAS No.: 138833-03-1
• Molecular Formula: C₁₅H₁₂F₂O₂
• Molecular Weight: 262.256
• Mol file: 138833-03-1.mol

Synonyms:benzyl 2,2-difluoro-2-phenylacetate

Chemical Property of benzyl 2,2-difluoro-2-phenylacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzyl 2,2-difluoro-2-phenylacetate

There total 4 articles about benzyl 2,2-difluoro-2-phenylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

α-diazo-α-phenylacetic acid benzyl ester (218792-82-6) → benzyl oxo(phenyl)acetate (62977-82-6) + benzyl 2,2-difluoro-2-phenylacetate (138833-03-1)

Guidance literature:

With 4-(difluoroiodo)toluene; boron trifluoride diethyl etherate; In chlorobenzene; at 110 ℃; for 0.0833333h;

DOI:10.1021/ja408678p

Reference yield: 76.0%

α-diazo-α-phenylacetic acid benzyl ester (218792-82-6) → benzyl 2,2-difluoro-2-phenylacetate (138833-03-1)

Guidance literature:

With 4-(difluoroiodo)toluene; chlorobenzene; at 110 ℃; Reagent/catalyst;

DOI:10.1002/ejoc.201600773

Reference yield: 74.0%

phenylacetyl chloride (103-80-0) + benzyl alcohol (100-51-6,185532-71-2) → benzyl 2,2-difluoro-2-phenylacetate (138833-03-1)

Guidance literature:

phenylacetyl chloride; With pyridine; tin(II) trifluoromethanesulfonate; Selectfluor; potassium tetrakis(pentafluorophenyl)borate; In acetonitrile; at 20 ℃; for 3h; Inert atmosphere;

benzyl alcohol; In acetonitrile; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/ol2019295

upstream raw materials:

phenylacetyl chloride

benzyl alcohol

α-diazo-α-phenylacetic acid benzyl ester

benzyl 2-phenylacetate

Downstream raw materials:

(R)-2-(benzyloxy)-3,3-difluoro-3-phenylpropanal

(R)-2-(benzyloxy)-3,3-difluoro-3-phenylpropan-1-ol

(2S)-2-(benzyloxy)-3,3-difluoro-3-phenyl-1(R)-<(4-methylphenyl)sulfinyl>propane

(S)-3,3-difluoro-3-phenyl-1-<(4-methylphenyl)thio>-propan-2-ol