(E)-ethyl 4-(4-(2-(1,3-diethyl-7-methyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)vinyl)-2-methoxyphenoxy)butanoate

Base Information

Chemical Name:(E)-ethyl 4-(4-(2-(1,3-diethyl-7-methyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)vinyl)-2-methoxyphenoxy)butanoate
CAS No.:1436428-56-6
Molecular Formula:C₂₅H₃₂N₄O₆
Molecular Weight:484.552
Hs Code.:

Synonyms:(E)-ethyl 4-(4-(2-(1,3-diethyl-7-methyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)vinyl)-2-methoxyphenoxy)butanoate

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Chemical Property of (E)-ethyl 4-(4-(2-(1,3-diethyl-7-methyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)vinyl)-2-methoxyphenoxy)butanoate

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Technology Process of (E)-ethyl 4-(4-(2-(1,3-diethyl-7-methyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)vinyl)-2-methoxyphenoxy)butanoate

There total 6 articles about (E)-ethyl 4-(4-(2-(1,3-diethyl-7-methyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)vinyl)-2-methoxyphenoxy)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 2969-81-5
Ethyl 4-bromobutyrate

: 160434-48-0
(E)-1,3-diethyl-8-(4-hydroxy-3-methoxystyryl)-7-methyl-1H-purine-2,6(3H,7H)-dione

: 1436428-56-6
(E)-ethyl 4-(4-(2-(1,3-diethyl-7-methyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)vinyl)-2-methoxyphenoxy)butanoate

Guidance literature:: With potassium carbonate; In acetone; for 72h; Reflux;
DOI:10.1016/j.bmcl.2013.03.070

Reference yield:

: 1436428-55-5
(E)-1,3-diethyl-8-(4-hydroxy-3-methoxystyryl)-1H-purine-2,6(3H,7H)-dione

: 1436428-56-6
(E)-ethyl 4-(4-(2-(1,3-diethyl-7-methyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)vinyl)-2-methoxyphenoxy)butanoate

Guidance literature:: Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran; N,N-dimethyl-formamide / 2 h / 0 °C / Darkness

2: potassium carbonate / acetone / 72 h / Reflux

With lithium aluminium tetrahydride; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide; acetone;
DOI:10.1016/j.bmcl.2013.03.070

Reference yield:

: 50906-12-2
4-acetoxy-3-methoxycinnamoyl chloride

: 1436428-56-6
(E)-ethyl 4-(4-(2-(1,3-diethyl-7-methyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)vinyl)-2-methoxyphenoxy)butanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine; dichloromethane / Inert atmosphere

1.2: 16 h / 20 °C / Inert atmosphere

2.1: 1,1,1,2,2,2-hexamethyldisilane; ammonium sulfate / acetonitrile / 1 h / 150 °C / 6750.68 Torr / Microwave irradiation; Inert atmosphere

3.1: lithium aluminium tetrahydride / tetrahydrofuran; N,N-dimethyl-formamide / 2 h / 0 °C / Darkness

4.1: potassium carbonate / acetone / 72 h / Reflux

With ammonium sulfate; lithium aluminium tetrahydride; 1,1,1,2,2,2-hexamethyldisilane; potassium carbonate; In tetrahydrofuran; pyridine; dichloromethane; N,N-dimethyl-formamide; acetone; acetonitrile;
DOI:10.1016/j.bmcl.2013.03.070