(E)-4-(3-((6-amino-1,3-diethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)amino)-3-oxoprop-1-en-1-yl)-2-methoxyphenyl acetate

Base Information

Chemical Name:(E)-4-(3-((6-amino-1,3-diethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)amino)-3-oxoprop-1-en-1-yl)-2-methoxyphenyl acetate
CAS No.:1436428-54-4
Molecular Formula:C₂₀H₂₄N₄O₆
Molecular Weight:416.434
Hs Code.:

Synonyms:(E)-4-(3-((6-amino-1,3-diethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)amino)-3-oxoprop-1-en-1-yl)-2-methoxyphenyl acetate

Suppliers and Price of (E)-4-(3-((6-amino-1,3-diethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)amino)-3-oxoprop-1-en-1-yl)-2-methoxyphenyl acetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (E)-4-(3-((6-amino-1,3-diethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)amino)-3-oxoprop-1-en-1-yl)-2-methoxyphenyl acetate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (E)-4-(3-((6-amino-1,3-diethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)amino)-3-oxoprop-1-en-1-yl)-2-methoxyphenyl acetate

There total 3 articles about (E)-4-(3-((6-amino-1,3-diethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)amino)-3-oxoprop-1-en-1-yl)-2-methoxyphenyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 39856-08-1,141236-46-6
(E)-3,4-dimethoxycinnamic chloride

: 50906-12-2
4-acetoxy-3-methoxycinnamoyl chloride

: 1436428-54-4
(E)-4-(3-((6-amino-1,3-diethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)amino)-3-oxoprop-1-en-1-yl)-2-methoxyphenyl acetate

Guidance literature:: (E)-3,4-dimethoxycinnamic chloride; In pyridine; dichloromethane; Inert atmosphere;

4-acetoxy-3-methoxycinnamoyl chloride; In pyridine; dichloromethane; at 20 ℃; for 16h; Inert atmosphere;
DOI:10.1016/j.bmcl.2013.03.070

Reference yield:

: 2596-47-6,147677-05-2,34749-55-8
(E)-3-(4-acetoxy-3-methoxyphenyl)acrylic acid

: 1436428-54-4
(E)-4-(3-((6-amino-1,3-diethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)amino)-3-oxoprop-1-en-1-yl)-2-methoxyphenyl acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: thionyl chloride / toluene / 16 h / Reflux

2.1: pyridine; dichloromethane / Inert atmosphere

2.2: 16 h / 20 °C / Inert atmosphere

With thionyl chloride; In pyridine; dichloromethane; toluene;
DOI:10.1016/j.bmcl.2013.03.070

Reference yield:

: 1135-24-6,537-98-4
(E)-3-(4-hydroxy-3-methoxyphenyl)acrylic acid

: 1436428-54-4
(E)-4-(3-((6-amino-1,3-diethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)amino)-3-oxoprop-1-en-1-yl)-2-methoxyphenyl acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: dmap / pyridine / 1 h / 0 °C

2.1: thionyl chloride / toluene / 16 h / Reflux

3.1: pyridine; dichloromethane / Inert atmosphere

3.2: 16 h / 20 °C / Inert atmosphere

With dmap; thionyl chloride; In pyridine; dichloromethane; toluene;
DOI:10.1016/j.bmcl.2013.03.070