4-DesMethyl Istradefylline

Base Information

Chemical Name:4-DesMethyl Istradefylline
CAS No.:160434-48-0
Molecular Formula:C19H22N4O4
Molecular Weight:370.408
Hs Code.:
Mol file:160434-48-0.mol

Synonyms:4-DesMethyl Istradefylline

Suppliers and Price of 4-DesMethyl Istradefylline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
4-Desmethyl Istradefylline
10mg
$ 496.00

TRC
4-DesmethylIstradefylline
10mg
$ 1540.00

Total 13 raw suppliers

Chemical Property of 4-DesMethyl Istradefylline

Chemical Property:

PSA：91.28000
LogP:1.82110

Purity/Quality:

97% ^*data from raw suppliers

4-Desmethyl Istradefylline ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses 4-Desmethyl Istradefylline is an impurity of Istradefylline (I927000), a selective A(2A) antagonist used in the treatment of Parkinson’s disease. 4-Desmethyl Istradefylline have also been shown to exhibit inhibitory potency towards adenosine A2A receptors and is classified as its an adenosine A2A receptor antagonist.

Technology Process of 4-DesMethyl Istradefylline

There total 6 articles about 4-DesMethyl Istradefylline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1436428-55-5
(E)-1,3-diethyl-8-(4-hydroxy-3-methoxystyryl)-1H-purine-2,6(3H,7H)-dione

: 74-88-4
methyl iodide

: 160434-48-0
(E)-1,3-diethyl-8-(4-hydroxy-3-methoxystyryl)-7-methyl-1H-purine-2,6(3H,7H)-dione

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; N,N-dimethyl-formamide; at 0 ℃; for 2h; Darkness;
DOI:10.1016/j.bmcl.2013.03.070

Reference yield:

: 155272-03-0
(E)-8-(3,4-Dihydroxystyryl)-1,3-diethyl-7-methylxanthine

: 74-88-4
methyl iodide

: 8-[(E)-2-(3-hydroxy-4-methoxyphenyl)vinyl]-1,3-diethyl-7-methylpurine-2,6-dione

: 160434-48-0
(E)-1,3-diethyl-8-(4-hydroxy-3-methoxystyryl)-7-methyl-1H-purine-2,6(3H,7H)-dione

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 25 - 30 ℃; Solvent;

Reference yield:

: 50906-12-2
4-acetoxy-3-methoxycinnamoyl chloride

: 160434-48-0
(E)-1,3-diethyl-8-(4-hydroxy-3-methoxystyryl)-7-methyl-1H-purine-2,6(3H,7H)-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine; dichloromethane / Inert atmosphere

1.2: 16 h / 20 °C / Inert atmosphere

2.1: 1,1,1,2,2,2-hexamethyldisilane; ammonium sulfate / acetonitrile / 1 h / 150 °C / 6750.68 Torr / Microwave irradiation; Inert atmosphere

3.1: lithium aluminium tetrahydride / tetrahydrofuran; N,N-dimethyl-formamide / 2 h / 0 °C / Darkness

With ammonium sulfate; lithium aluminium tetrahydride; 1,1,1,2,2,2-hexamethyldisilane; In tetrahydrofuran; pyridine; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmcl.2013.03.070