4-<4-amino-3-(N-metylaminomethyl)phenyl>-1-(3,4-dimethoxybenzoyl)piperazine

Base Information

Chemical Name:4-<4-amino-3-(N-metylaminomethyl)phenyl>-1-(3,4-dimethoxybenzoyl)piperazine
CAS No.:119198-38-8
Molecular Formula:C₂₁H₂₈N₄O₃
Molecular Weight:384.478
Hs Code.:

Synonyms:4-<4-amino-3-(N-metylaminomethyl)phenyl>-1-(3,4-dimethoxybenzoyl)piperazine

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Chemical Property of 4-<4-amino-3-(N-metylaminomethyl)phenyl>-1-(3,4-dimethoxybenzoyl)piperazine

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Technology Process of 4-<4-amino-3-(N-metylaminomethyl)phenyl>-1-(3,4-dimethoxybenzoyl)piperazine

There total 5 articles about 4-<4-amino-3-(N-metylaminomethyl)phenyl>-1-(3,4-dimethoxybenzoyl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 119198-37-7
1-(3,4-dimetoxybenzoyl)-4-<3-(N-methylaminomethyl)-4-nitrophenyl>piperazine

: 119198-38-8
4-<4-amino-3-(N-metylaminomethyl)phenyl>-1-(3,4-dimethoxybenzoyl)piperazine

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; Ambient temperature;
DOI:10.1248/cpb.36.2401

Reference yield:

: 13796-06-0
2-nitro-5-chlorobenzaldehyde dimethyl acetal

: 119198-38-8
4-<4-amino-3-(N-metylaminomethyl)phenyl>-1-(3,4-dimethoxybenzoyl)piperazine

Guidance literature:: Multi-step reaction with 5 steps

1: 63 percent / dimethylformamide / 4 h / 80 °C

2: 73 percent / triethyl amine / dimethylformamide / 2 h / Ambient temperature

3: CHCl₃; methanol / 6 h / Ambient temperature

4: NaBH₄ / CHCl₃; methanol / 3 h / Ambient temperature

5: 90 percent / H₂ / Pd - C (5percent) / ethanol / Ambient temperature

With sodium tetrahydroborate; hydrogen; triethylamine; palladium on activated charcoal; In methanol; ethanol; chloroform; N,N-dimethyl-formamide;
DOI:10.1248/cpb.36.2401

Reference yield:

: 81840-07-5
1-(3,4-dimethoxybenzoyl)-4-(3-formyl-4-nitrophenyl)piperazine

: 119198-38-8
4-<4-amino-3-(N-metylaminomethyl)phenyl>-1-(3,4-dimethoxybenzoyl)piperazine

Guidance literature:: Multi-step reaction with 3 steps

1: CHCl₃; methanol / 6 h / Ambient temperature

2: NaBH₄ / CHCl₃; methanol / 3 h / Ambient temperature

3: 90 percent / H₂ / Pd - C (5percent) / ethanol / Ambient temperature

With sodium tetrahydroborate; hydrogen; palladium on activated charcoal; In methanol; ethanol; chloroform;
DOI:10.1248/cpb.36.2401