2-(DIMETHYLAMINO)-6-(TRIFLUOROMETHYL)-4-PYRIMIDINOL

Base Information

• Chemical Name: 2-(DIMETHYLAMINO)-6-(TRIFLUOROMETHYL)-4-PYRIMIDINOL
• CAS No.: 55545-80-7
• Molecular Formula: C7H8 F3 N3 O
• Molecular Weight: 207.155
• Hs Code.: 2933599090
• Mol file: 55545-80-7.mol

Synonyms:4(1H)-Pyrimidinone,2-(dimethylamino)-6-(trifluoromethyl)- (9CI);2-(Dimethylamino)-6-hydroxy-4-(trifluoromethyl)pyrimidine

Chemical Property of 2-(DIMETHYLAMINO)-6-(TRIFLUOROMETHYL)-4-PYRIMIDINOL

Chemical Property:

• Vapor Pressure: 0.722mmHg at 25°C
• Melting Point: 176-177°C
• Boiling Point: 184.7ºC at 760 mmHg
• Flash Point: 65.5ºC
• PSA: 49.25000
• Density: 1.41g/cm3
• LogP: 1.26700

Purity/Quality:

98%Min ^*data from raw suppliers

2-(Dimethylamino)-6-(trifluoromethyl)-4-pyrimidinol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(DIMETHYLAMINO)-6-(TRIFLUOROMETHYL)-4-PYRIMIDINOL

There total 2 articles about 2-(DIMETHYLAMINO)-6-(TRIFLUOROMETHYL)-4-PYRIMIDINOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.4%

N,N-dimethylguanidinium hydrochloride (22583-29-5) + ethyl 4,4,4-trifluoroacetoacetate (372-31-6) → 2-dimethylamino-4-trifluoromethyl-6-pyrimidinol (55545-80-7)

Guidance literature:

With ethanol; sodium; In ethanol; 1) 1h, reflux 2) r.t.;

DOI:10.1007/BF00808930

Reference yield:

ethyl 4,4,4-trifluoroacetoacetate (372-31-6) + N,N-Dimethyl-guanidine (6145-42-2) → 2-dimethylamino-4-trifluoromethyl-6-pyrimidinol (55545-80-7)

Guidance literature:

With sodium methylate; In methanol;

DOI:10.1016/j.bmcl.2013.04.045

Reference yield: 72.0%

methyl (E)-3-methoxy-2-(2-chloromethylphenyl)acrylate (117428-51-0) + 2-dimethylamino-4-trifluoromethyl-6-pyrimidinol (55545-80-7) → (E)-methyl 2-(2-(((2-(dimethylamino)-6-(trifluoromethyl)pyrimidin-4-yl)oxy)methyl)phenyl)-3-methoxyacrylate (145910-88-9)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 8h;

DOI:10.1016/j.bmcl.2013.04.045

upstream raw materials:

N,N-dimethylguanidinium hydrochloride

ethyl 4,4,4-trifluoroacetoacetate

N,N-Dimethyl-guanidine

Downstream raw materials:

C₁₉H₂₀F₃N₃O₄

(E)-methyl 2-(2-(((2-(dimethylamino)-6-(trifluoromethyl)pyrimidin-4-yl)oxy)methyl)phenyl)-3-methoxyacrylate

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