(E)-1-(1-benzyl-4-(3,5-difluoro-4'-methoxy-[1,1'-biphenyl]-4-yl)-2-methyl-1H-pyrrol-3-yl)ethanone oxime

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Chemical Name:(E)-1-(1-benzyl-4-(3,5-difluoro-4'-methoxy-[1,1'-biphenyl]-4-yl)-2-methyl-1H-pyrrol-3-yl)ethanone oxime
CAS No.:1318763-73-3
Molecular Formula:C₂₇H₂₄F₂N₂O₂
Molecular Weight:446.497
Hs Code.:

Synonyms:(E)-1-(1-benzyl-4-(3,5-difluoro-4'-methoxy-[1,1'-biphenyl]-4-yl)-2-methyl-1H-pyrrol-3-yl)ethanone oxime

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Chemical Property of (E)-1-(1-benzyl-4-(3,5-difluoro-4'-methoxy-[1,1'-biphenyl]-4-yl)-2-methyl-1H-pyrrol-3-yl)ethanone oxime

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Technology Process of (E)-1-(1-benzyl-4-(3,5-difluoro-4'-methoxy-[1,1'-biphenyl]-4-yl)-2-methyl-1H-pyrrol-3-yl)ethanone oxime

There total 4 articles about (E)-1-(1-benzyl-4-(3,5-difluoro-4'-methoxy-[1,1'-biphenyl]-4-yl)-2-methyl-1H-pyrrol-3-yl)ethanone oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1318763-72-2
1-(1-benzyl-4-(3,5-difluoro-4'-methoxy-[1,1'-biphenyl]-4-yl)-2-methyl-1H-pyrrol-3-yl)ethanone

: 1318763-73-3
(E)-1-(1-benzyl-4-(3,5-difluoro-4'-methoxy-[1,1'-biphenyl]-4-yl)-2-methyl-1H-pyrrol-3-yl)ethanone oxime

Guidance literature:: With hydroxylamine hydrochloride; sodium acetate; In ethanol; water; at 20 - 85 ℃; for 3.25h; Inert atmosphere;
DOI:10.1039/c1cc12321a

Reference yield:

: 537013-51-7
4-bromo-2,6-difluorobenzaldehyde

: 1318763-73-3
(E)-1-(1-benzyl-4-(3,5-difluoro-4'-methoxy-[1,1'-biphenyl]-4-yl)-2-methyl-1H-pyrrol-3-yl)ethanone oxime

Guidance literature:: Multi-step reaction with 2 steps

1.1: bis-triphenylphosphine-palladium(II) chloride / 4 h / 80 - 85 °C / Inert atmosphere; Neat (no solvent)

1.2: 5 h / 80 - 85 °C / Inert atmosphere

2.1: hydroxylamine hydrochloride; sodium acetate / ethanol; water / 3.25 h / 20 - 85 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; hydroxylamine hydrochloride; sodium acetate; In ethanol; water; 1.1: Suzuki coupling / 1.2: Suzuki coupling;
DOI:10.1039/c1cc12321a

Reference yield:

: 100-46-9
benzylamine

: 1318763-73-3
(E)-1-(1-benzyl-4-(3,5-difluoro-4'-methoxy-[1,1'-biphenyl]-4-yl)-2-methyl-1H-pyrrol-3-yl)ethanone oxime

Guidance literature:: Multi-step reaction with 2 steps

1.1: bis-triphenylphosphine-palladium(II) chloride / 4 h / 80 - 85 °C / Inert atmosphere; Neat (no solvent)

1.2: 5 h / 80 - 85 °C / Inert atmosphere

2.1: hydroxylamine hydrochloride; sodium acetate / ethanol; water / 3.25 h / 20 - 85 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; hydroxylamine hydrochloride; sodium acetate; In ethanol; water; 1.1: Suzuki coupling / 1.2: Suzuki coupling;
DOI:10.1039/c1cc12321a