(1R)-4-methyl-1-[(1R)-1-methyl-2-methylidenecyclopentyl]cyclohex-3-ene-1-carboxylic acid

Base Information

• Chemical Name: (1R)-4-methyl-1-[(1R)-1-methyl-2-methylidenecyclopentyl]cyclohex-3-ene-1-carboxylic acid
• CAS No.: 105164-34-9
• Molecular Formula: C₁₅H₂₂O₂
• Molecular Weight: 234.338
• Mol file: 105164-34-9.mol

Synonyms:3-Cyclohexene-1-carboxylicacid, 4-methyl-1-(1-methyl-2-methylenecyclopentyl)-, (R*,R*)- (9CI);3-Cyclohexene-1-carboxylic acid, 4-methyl-1-(1-methyl-2-methylenecyclopentyl)-,(R*,R*)-(?à)-

Chemical Property of (1R)-4-methyl-1-[(1R)-1-methyl-2-methylidenecyclopentyl]cyclohex-3-ene-1-carboxylic acid

Chemical Property:

• Vapor Pressure: 9.65E-06mmHg at 25°C
• Boiling Point: 347.1°Cat760mmHg
• Flash Point: 166.9°C
• Density: 1.05g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R)-4-methyl-1-[(1R)-1-methyl-2-methylidenecyclopentyl]cyclohex-3-ene-1-carboxylic acid

There total 4 articles about (1R)-4-methyl-1-[(1R)-1-methyl-2-methylidenecyclopentyl]cyclohex-3-ene-1-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C18H30O2Si → 4-Methyl-1-(1-methyl-2-methylene-cyclopentyl)-cyclohex-3-enecarboxylic acid (105164-35-0,105164-34-9)

Guidance literature:

With tetrabutyl ammonium fluoride; In diethyl ether;

DOI:10.1021/jo00373a032

Reference yield:

(2-methyl-1-cyclopentenyl)methyl 4-methyl-3-cyclohexene-1-carboxylate (104762-26-7) → 4-Methyl-1-(1-methyl-2-methylene-cyclopentyl)-cyclohex-3-enecarboxylic acid (105164-35-0,105164-34-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) LDA

2: n-Bu₄NF / diethyl ether

With tetrabutyl ammonium fluoride; lithium diisopropyl amide; In diethyl ether;

DOI:10.1021/jo00373a032

Reference yield:

(4'-methylcyclohex-3'-ene-1-'-yl)carbonyl chloride (16695-95-7) → 4-Methyl-1-(1-methyl-2-methylene-cyclopentyl)-cyclohex-3-enecarboxylic acid (105164-35-0,105164-34-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 81 percent / pyridine / 12 h / Ambient temperature

2: 1.) LDA

3: n-Bu₄NF / diethyl ether

With pyridine; tetrabutyl ammonium fluoride; lithium diisopropyl amide; In diethyl ether;

DOI:10.1021/jo00373a032

upstream raw materials:

(2-methyl-1-cyclopentenyl)methyl 4-methyl-3-cyclohexene-1-carboxylate

(4'-methylcyclohex-3'-ene-1-'-yl)carbonyl chloride

isoprene

Downstream raw materials:

methyl 4-methyl-1-(1-methyl-2-methylenecyclopentyl)-3-cyclohexene-1-carboxylate