(2R)-2-(N-tert-butoxycarbonyl-N-methylamino)-3-methyl-1-phenyl-1-butanol

Base Information

Chemical Name:(2R)-2-(N-tert-butoxycarbonyl-N-methylamino)-3-methyl-1-phenyl-1-butanol
CAS No.:698353-14-9
Molecular Formula:C₁₇H₂₇NO₃
Molecular Weight:293.406
Hs Code.:

Synonyms:(2R)-2-(N-tert-butoxycarbonyl-N-methylamino)-3-methyl-1-phenyl-1-butanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R)-2-(N-tert-butoxycarbonyl-N-methylamino)-3-methyl-1-phenyl-1-butanol

Chemical Property:

Purity/Quality:

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Technology Process of (2R)-2-(N-tert-butoxycarbonyl-N-methylamino)-3-methyl-1-phenyl-1-butanol

There total 1 articles about (2R)-2-(N-tert-butoxycarbonyl-N-methylamino)-3-methyl-1-phenyl-1-butanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100-52-7
benzaldehyde

: 140175-19-5,140384-74-3
Methyl-((S)-2-methyl-1-tributylstannanyl-propyl)-carbamic acid tert-butyl ester

: 698353-14-9
(2R)-2-(N-tert-butoxycarbonyl-N-methylamino)-3-methyl-1-phenyl-1-butanol

Guidance literature:: Methyl-((S)-2-methyl-1-tributylstannanyl-propyl)-carbamic acid tert-butyl ester; With n-butyllithium; In tetrahydrofuran; hexane; at -95 ℃; for 0.25h;

benzaldehyde; In tetrahydrofuran; hexane; at -95 ℃; for 0.166667h;
DOI:10.1139/v03-165

Reference yield: 95.0%

: 698353-14-9
(2R)-2-(N-tert-butoxycarbonyl-N-methylamino)-3-methyl-1-phenyl-1-butanol

: 698353-16-1
(R)-2-(N-tert-butoxycarbonyl-N-methylamino)-3-methyl-1-phenyl-1-butanone

Guidance literature:: With tetrapropylammonium perruthennate; 4 A molecular sieve; 4-methylmorpholine N-oxide; In dichloromethane; for 1h;
DOI:10.1139/v03-165

Reference yield:

: 698353-14-9
(2R)-2-(N-tert-butoxycarbonyl-N-methylamino)-3-methyl-1-phenyl-1-butanol

: (1R,2R)-2-(N-tert-butoxycarbonyl-N-methylamino)-3-methyl-1-phenyl-1-butanol

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / N-methylmorpholine-N-oxide; 4 Angstroem molecular sieves; tetrapropylammonium perruthenate / CH₂Cl₂ / 1 h

2: 88 percent / Super-hydride(R) / tetrahydrofuran / 0.25 h / -78 °C

With tetrapropylammonium perruthennate; 4 A molecular sieve; lithium triethylborohydride; 4-methylmorpholine N-oxide; In tetrahydrofuran; dichloromethane;
DOI:10.1139/v03-165