Technology Process of 4-(5-(1-methyl-5-phenyl-1H-pyrazol-3-yl)-1,2,4-oxadiazol-3-yl)benzaldehyde
There total 5 articles about 4-(5-(1-methyl-5-phenyl-1H-pyrazol-3-yl)-1,2,4-oxadiazol-3-yl)benzaldehyde which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
Dess-Martin periodane;
In
dichloromethane; dimethyl sulfoxide;
at 20 ℃;
for 2h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 2 h / 140 °C / Inert atmosphere
2: Dess-Martin periodane / dichloromethane; dimethyl sulfoxide / 2 h / 20 °C / Inert atmosphere
With
benzotriazol-1-ol; Dess-Martin periodane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: ethanol / 2.25 h / 20 °C / Inert atmosphere; Reflux
2: lithium hydroxide / ethanol; water / 0.5 h / 65 °C
3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 2 h / 140 °C / Inert atmosphere
4: Dess-Martin periodane / dichloromethane; dimethyl sulfoxide / 2 h / 20 °C / Inert atmosphere
With
lithium hydroxide; benzotriazol-1-ol; Dess-Martin periodane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;