Technology Process of [3-({4-[5-(1-methyl-5-phenyl-1H-pyrazol-3-yl)-1,2,4-oxadiazol-3-yl]benzyl}amino)propyl]phosphonic acid
There total 6 articles about [3-({4-[5-(1-methyl-5-phenyl-1H-pyrazol-3-yl)-1,2,4-oxadiazol-3-yl]benzyl}amino)propyl]phosphonic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
3-aminopropanephosphonic acid; 4-(5-(1-methyl-5-phenyl-1H-pyrazol-3-yl)-1,2,4-oxadiazol-3-yl)benzaldehyde;
With
tetra(n-butyl)ammonium hydroxide;
In
methanol;
at 50 ℃;
for 1h;
With
sodium tetrahydroborate;
In
methanol;
at 20 ℃;
for 3h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 2 h / 140 °C / Inert atmosphere
2.1: Dess-Martin periodane / dichloromethane; dimethyl sulfoxide / 2 h / 20 °C / Inert atmosphere
3.1: tetra(n-butyl)ammonium hydroxide / methanol / 1 h / 50 °C
3.2: 3 h / 20 °C
With
tetra(n-butyl)ammonium hydroxide; benzotriazol-1-ol; Dess-Martin periodane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 2 h / 140 °C / Inert atmosphere
2.1: Dess-Martin periodane / dichloromethane; dimethyl sulfoxide / 2 h / 20 °C / Inert atmosphere
3.1: tetra(n-butyl)ammonium hydroxide / methanol / 1 h / 50 °C
3.2: 3 h / 20 °C
With
tetra(n-butyl)ammonium hydroxide; benzotriazol-1-ol; Dess-Martin periodane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;