4'-Formylbiphenyl-2-carboxylic acid

Base Information

• Chemical Name: 4'-Formylbiphenyl-2-carboxylic acid
• CAS No.: 112804-58-7
• Molecular Formula: C₁₄H₁₀O₃
• Molecular Weight: 226.232
• Hs Code.: 2916399090
• European Community (EC) Number: 672-476-3
• DSSTox Substance ID: DTXSID50383355
• Wikidata: Q82175030
• Mol file: 112804-58-7.mol

Synonyms:112804-58-7;4'-Formylbiphenyl-2-carboxylic acid;2-(4-formylphenyl)benzoic Acid;4'-Formyl-[1,1'-biphenyl]-2-carboxylic acid;4'-Formyl-biphenyl-2-carboxylic acid;4'-Formyl[1,1'-biphenyl]-2-carboxylic acid;2-BIPHENYL-4'-FORMYL-CARBOXYLIC ACID;MFCD03426394;4'-Formylbiphenyl-2-carboxylicAcid;[1,1'-Biphenyl]-2-carboxylic acid, 4'-formyl-;SCHEMBL9597954;DTXSID50383355;4`-Formylbiphenyl-2-carboxylic Acid;AKOS004114054;CS-11354;SY017023;BB 0222588;CS-0171205;FT-0726659;4'-Formyl-[1,1'-biphenyl]-2-carboxylicacid;A13336;EN300-842817;Z1741960867;4 inverted exclamation mark -Formylbiphenyl-2-carboxylic Acid

Chemical Property of 4'-Formylbiphenyl-2-carboxylic acid

Chemical Property:

• Melting Point: 167 °C
• Boiling Point: 407.4 °C at 760 mmHg
• PKA: 3.73±0.36(Predicted)
• Flash Point: 214.4 °C
• PSA: 54.37000
• Density: 1.264 g/cm³
• LogP: 2.86430
• Storage Temp.: 2-8°C
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 226.062994177
• Heavy Atom Count: 17
• Complexity: 279

Purity/Quality:

97% ^*data from raw suppliers

4''-Formyl-[1,1''-biphenyl]-2-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)C2=CC=C(C=C2)C=O)C(=O)O
• Uses: 4'-Formyl-[1,1'-biphenyl]-2-carboxylic acid is an impurity of Telmisartan (T017000), an angiotensin II receptor antagonist. 4''-Formyl-[1,1''-biphenyl]-2-carboxylic acid is an impurity of Telmisartan (T017000), an angiotensin II receptor antagonist.

Technology Process of 4'-Formylbiphenyl-2-carboxylic acid

There total 3 articles about 4'-Formylbiphenyl-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(2-Methoxycarbonyl-phenyl)-Benzaldehyde (144291-47-4) → 4'-formyl-[1,1'-biphenyl]-2-carboxylic acid (112804-58-7)

Guidance literature:

With water; sodium hydroxide; In tetrahydrofuran; at 80 ℃;

DOI:10.1002/chem.201303511

Reference yield:

4-formylphenylboronic acid, (87199-17-5) → 4'-formyl-[1,1'-biphenyl]-2-carboxylic acid (112804-58-7)

Guidance literature:

Multi-step reaction with 2 steps

1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / tetrahydrofuran; water / 20 - 80 °C / Schlenk technique; Inert atmosphere

2: sodium hydroxide; water / tetrahydrofuran / 80 °C

With bis-triphenylphosphine-palladium(II) chloride; water; sodium carbonate; sodium hydroxide; In tetrahydrofuran; water; 1: |Suzuki Coupling;

DOI:10.1002/chem.201303511

Reference yield:

o-iodo-methyl-benzoic acid (610-97-9) → 4'-formyl-[1,1'-biphenyl]-2-carboxylic acid (112804-58-7)

Guidance literature:

Multi-step reaction with 2 steps

1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / tetrahydrofuran; water / 20 - 80 °C / Schlenk technique; Inert atmosphere

2: sodium hydroxide; water / tetrahydrofuran / 80 °C

With bis-triphenylphosphine-palladium(II) chloride; water; sodium carbonate; sodium hydroxide; In tetrahydrofuran; water; 1: |Suzuki Coupling;

DOI:10.1002/chem.201303511

upstream raw materials:

4-formylphenylboronic acid,

4-(2-Methoxycarbonyl-phenyl)-Benzaldehyde

o-iodo-methyl-benzoic acid

Downstream raw materials:

4'-[(Benzimidazol-1-yl)-methyl]biphenyl-2-carboxylic acid

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 112804-58-7 4'-FORMYL-BIPHENYL-2-CARBOXYLIC ACID

Send

Send

Metric Ton KG G Pound L ML

Send

Send