144291-47-4

Basic information

• Product Name: Methyl 2-(4-formylphenyl)benzoate
• Synonyms: Methyl 2-(4-formylphenyl)benzoate
• CAS NO: 144291-47-4
• Molecular Formula: C₁₅H₁₂O₃
• Molecular Weight: 240.25
• Mol File: 144291-47-4.mol
• Article Data: 13

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: Methyl 2-(4-formylphenyl)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 2-(4-formylphenyl)benzoate(144291-47-4)
• EPA Substance Registry System: Methyl 2-(4-formylphenyl)benzoate(144291-47-4)

Safety Data

• Hazardous Substances Data: 144291-47-4(Hazardous Substances Data)

Usage

Uses

Methyl 2-(4-Formylphenyl)benzoate is a useful synthetic compound.

Upstream product

• 67-56-1 methanol 
• 88-67-5 2-Iodobenzoic acid 
• 87199-17-5 4-formylphenylboronic acid, 
• 88-65-3 2-bromobenzoic-acid 
• 610-97-9 o-iodo-methyl-benzoic acid 
• 114772-38-2 Methyl 4'-(bromomethyl)biphenyl-2-carboxylate 
• 610-94-6 2-bromobenzoic acid methyl ester 

Downstream Products

• 158144-55-9 methyl 4'-(hydroxymethyl)biphenyl-2-carboxylate 

Relevant articles and documents

Poly(ethylene glycol) supported liquid phase synthesis of biaryls

The liquid phase synthesis of biaiyls via Suzuki cross-coupling reaction on polyethylene glycol) supports (PEGs) is described. The reaction is exemplified by parallel coupling of polymer bound aryl halides with boronic acids. Four different PEGs were employed as soluble polymer supports for parallel synthesis. The generated libraries include both sterically hindered aryl halides (2b, 2d) and boronic acids. The reactions were run in the homogeneous phase and the synthetic sequences performed in parallel fashion. Quantitative conversion in the Suzuki couplings was verified by 1H-NMR analysis (3a-r). The polymer bound products were isolated in good to excellent (52% to 98%) yields by either simple precipitation of the soluble support or column filtration.

Discovery of ONO-7300243 from a Novel Class of Lysophosphatidic Acid Receptor 1 Antagonists: From Hit to Lead

Lysophosphatidic acid (LPA) evokes various physiological responses through a series of G protein-coupled receptors known as LPA1-6. A high throughput screen against LPA1 gave compound 7a as a hit. The subsequent optimization of 7a led to ONO-7300243 (17a) as a novel, potent LPA1 antagonist, which showed good efficacy in vivo. The oral dosing of 17a at 30 mg/kg led to reduced intraurethral pressure in rats. Notably, this compound was equal in potency to the α1 adrenoceptor antagonist tamsulosin, which is used in clinical practice to treat dysuria with benign prostatic hyperplasia (BPH). In contrast to tamsulosin, compound 17a had no impact on the mean blood pressure at this dose. These results suggest that LPA1 antagonists could be used to treat BPH without affecting the blood pressure. Herein, we report the hit-to-lead optimization of a unique series of LPA1 antagonists and their in vivo efficacy.

General and practical carboxyl-group-directed remote C-H oxygenation reactions of arenes

Two methods for remote aromatic C-H oxygenation reactions, have been developed. Method1, the Cu-catalyzed oxygenation reaction, is highly efficient for cyclization of electron-neutral and electron-rich biaryl carboxylic acids into 3,4-benzocoumarins. Method2, the K2S2O 8-mediated oxygenation reaction, is more general and practical for cyclization of substrates with electron-donating and -withdrawing groups (see scheme). Copyright