Technology Process of 7,7-bis(phenylsulfonyl)heptanoic acid 5-(3-vinyloxiranyl)pentyl ester
There total 8 articles about 7,7-bis(phenylsulfonyl)heptanoic acid 5-(3-vinyloxiranyl)pentyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
dichloromethane;
at 0 - 20 ℃;
for 12h;
DOI:10.1039/c3ob41020j
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium hydride / mineral oil; tetrahydrofuran / 2 h / 20 °C
1.2: 20 °C
2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1.5 h / -78 °C / Inert atmosphere
2.2: -78 - 20 °C / Inert atmosphere
3.1: sodium hydroxide; benzyltrimethylammonium chloride / methanol; dichloromethane / -20 - 20 °C
4.1: ammonium fluoride / methanol / 8 h / Reflux
5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 12 h / 0 - 20 °C
With
dmap; ammonium fluoride; oxalyl dichloride; benzyltrimethylammonium chloride; sodium hydride; dimethyl sulfoxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; mineral oil;
2.1: |Swern Oxidation / 2.2: |Swern Oxidation;
DOI:10.1039/c3ob41020j
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sulfuric acid / Reflux
2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1.5 h / Cooling with ice; Schlenk technique; Inert atmosphere
2.2: 60 °C / Inert atmosphere; Schlenk technique
3.1: lithium hydroxide / tetrahydrofuran; methanol / 18 h / 40 °C
3.2: pH 1
4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 12 h / 0 - 20 °C
With
dmap; sulfuric acid; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1039/c3ob41020j
