(E)-3-isopropylidene-4-<1-<2-methyl-1-(4-tolylsulfonyl)-3-indolyl>ethylidene>-3,4-dihydro-2,5-furandione

Base Information

Chemical Name:(E)-3-isopropylidene-4-<1-<2-methyl-1-(4-tolylsulfonyl)-3-indolyl>ethylidene>-3,4-dihydro-2,5-furandione
CAS No.:171922-91-1
Molecular Formula:C₂₅H₂₃NO₅S
Molecular Weight:449.527
Hs Code.:

Synonyms:(E)-3-isopropylidene-4-<1-<2-methyl-1-(4-tolylsulfonyl)-3-indolyl>ethylidene>-3,4-dihydro-2,5-furandione

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Chemical Property of (E)-3-isopropylidene-4-<1-<2-methyl-1-(4-tolylsulfonyl)-3-indolyl>ethylidene>-3,4-dihydro-2,5-furandione

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Technology Process of (E)-3-isopropylidene-4-<1-<2-methyl-1-(4-tolylsulfonyl)-3-indolyl>ethylidene>-3,4-dihydro-2,5-furandione

There total 6 articles about (E)-3-isopropylidene-4-<1-<2-methyl-1-(4-tolylsulfonyl)-3-indolyl>ethylidene>-3,4-dihydro-2,5-furandione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 201230-82-2
carbon monoxide

: 171922-94-4
5-methyl-2-<2-methyl-1-(4-tolylsulfonyl)-3-indolyl>-3-hexyne-2,5-diol

: 171922-91-1
(E)-3-isopropylidene-4-<1-<2-methyl-1-(4-tolylsulfonyl)-3-indolyl>ethylidene>-3,4-dihydro-2,5-furandione

: 171922-92-2
(Z)-3-isopropylidene-4-<1-<2-methyl-1-(4-tolylsulfonyl)-3-indolyl>ethylidene>-3,4-dihydro-2,5-furandione

Guidance literature:: With palladium diacetate; iodine; In benzene; at 90 ℃; for 6h; under 53254.2 Torr;
DOI:10.1246/bcsj.68.2961

Reference yield:

: 22582-52-1
3-acetyl-2-methylindole

: 171922-91-1
(E)-3-isopropylidene-4-<1-<2-methyl-1-(4-tolylsulfonyl)-3-indolyl>ethylidene>-3,4-dihydro-2,5-furandione

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaH / 1.) THF, RT, 30 min, 2.) THF, RT, 2 h

2: 1.) CeCl₃, 2.) BuLi / 1.) THF, RT, 3 h, 2.) THF, hexane, a) -78 deg C, 3 h, b) from -78 deg C to RT, overnight

3: Pd(OAc)2, I₂ / benzene / 6 h / 90 °C / 53254.2 Torr

With palladium diacetate; n-butyllithium; cerium(III) chloride; iodine; sodium hydride; In benzene;
DOI:10.1246/bcsj.68.2961

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 171922-91-1
(E)-3-isopropylidene-4-<1-<2-methyl-1-(4-tolylsulfonyl)-3-indolyl>ethylidene>-3,4-dihydro-2,5-furandione

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaH / 1.) THF, RT, 30 min, 2.) THF, RT, 2 h

2: 1.) CeCl₃, 2.) BuLi / 1.) THF, RT, 3 h, 2.) THF, hexane, a) -78 deg C, 3 h, b) from -78 deg C to RT, overnight

3: Pd(OAc)2, I₂ / benzene / 6 h / 90 °C / 53254.2 Torr

With palladium diacetate; n-butyllithium; cerium(III) chloride; iodine; sodium hydride; In benzene;
DOI:10.1246/bcsj.68.2961