N-p-toluenesulfonyl-4-(t-butyldimethylsilyloxy)-7-chloro-1,2-dihydroquinoline

Base Information

Chemical Name:N-p-toluenesulfonyl-4-(t-butyldimethylsilyloxy)-7-chloro-1,2-dihydroquinoline
CAS No.:675578-65-1
Molecular Formula:C₂₂H₂₈ClNO₃SSi
Molecular Weight:450.074
Hs Code.:

Synonyms:N-p-toluenesulfonyl-4-(t-butyldimethylsilyloxy)-7-chloro-1,2-dihydroquinoline

Suppliers and Price of N-p-toluenesulfonyl-4-(t-butyldimethylsilyloxy)-7-chloro-1,2-dihydroquinoline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-p-toluenesulfonyl-4-(t-butyldimethylsilyloxy)-7-chloro-1,2-dihydroquinoline

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Technology Process of N-p-toluenesulfonyl-4-(t-butyldimethylsilyloxy)-7-chloro-1,2-dihydroquinoline

There total 4 articles about N-p-toluenesulfonyl-4-(t-butyldimethylsilyloxy)-7-chloro-1,2-dihydroquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 675578-64-0
N-allyl-N-p-toluenesulfonyl-2-[1-(tert-butyldimethylsilyloxy)vinyl]-5-chloroaniline

: 675578-65-1
N-p-toluenesulfonyl-4-(t-butyldimethylsilyloxy)-7-chloro-1,2-dihydroquinoline

Guidance literature:: With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)imidazol-2-ylidene](benzylidene)Ru(II) dichloride; In dichloromethane; at 50 ℃; for 1h;
DOI:10.1016/j.tet.2004.01.084

Reference yield:

: 39061-72-8
2-acetyl-5-chloroaniline

: 675578-65-1
N-p-toluenesulfonyl-4-(t-butyldimethylsilyloxy)-7-chloro-1,2-dihydroquinoline

Guidance literature:: Multi-step reaction with 4 steps

1: 75 percent / pyridine / CH₂Cl₂ / 1 h / 20 °C

2: 95 percent / K₂CO₃ / dimethylformamide / 1 h / 80 °C

3: 98 percent / NaI; Et₃N / acetonitrile / 1 h / Heating

4: 95 percent / Cl₂Ru(PCy₃)(=CHPh)(N,N'-(Mes)2-imidazolidin-2-yl) / CH₂Cl₂ / 1 h / 50 °C

With pyridine; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)imidazol-2-ylidene](benzylidene)Ru(II) dichloride; potassium carbonate; triethylamine; sodium iodide; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.tet.2004.01.084

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 675578-65-1
N-p-toluenesulfonyl-4-(t-butyldimethylsilyloxy)-7-chloro-1,2-dihydroquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / NaI; Et₃N / acetonitrile / 1 h / Heating

2: 95 percent / Cl₂Ru(PCy₃)(=CHPh)(N,N'-(Mes)2-imidazolidin-2-yl) / CH₂Cl₂ / 1 h / 50 °C

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)imidazol-2-ylidene](benzylidene)Ru(II) dichloride; triethylamine; sodium iodide; In dichloromethane; acetonitrile;
DOI:10.1016/j.tet.2004.01.084