(E)-1-(4-methoxyphenyl)-3-methylbut-3-en-1-one oxime

Base Information

• Chemical Name: (E)-1-(4-methoxyphenyl)-3-methylbut-3-en-1-one oxime
• CAS No.: 1221447-10-4
• Molecular Formula: C₁₂H₁₅NO₂
• Molecular Weight: 205.257
• Mol file: 1221447-10-4.mol

Synonyms:(E)-1-(4-methoxyphenyl)-3-methylbut-3-en-1-one oxime

Chemical Property of (E)-1-(4-methoxyphenyl)-3-methylbut-3-en-1-one oxime

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of (E)-1-(4-methoxyphenyl)-3-methylbut-3-en-1-one oxime

There total 2 articles about (E)-1-(4-methoxyphenyl)-3-methylbut-3-en-1-one oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

3-methyl-1-(4'-methoxyphenyl)-3-buten-1-ol (151453-09-7) → (E)-1-(4-methoxyphenyl)-3-methylbut-3-en-1-one oxime (1221447-10-4)

Guidance literature:

With hydroxylamine hydrochloride; sodium acetate; In ethanol; water; at 20 ℃; for 18h; Inert atmosphere;

DOI:10.1039/d1cc02587b

Reference yield:

4-methoxy-benzaldehyde (123-11-5) → (E)-1-(4-methoxyphenyl)-3-methylbut-3-en-1-one oxime (1221447-10-4)

Guidance literature:

Multi-step reaction with 2 steps

1: activated zinc / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2: sodium acetate; hydroxylamine hydrochloride / water; ethanol / 18 h / 20 °C / Inert atmosphere

With hydroxylamine hydrochloride; sodium acetate; In tetrahydrofuran; ethanol; water;

DOI:10.1039/d1cc02587b

Reference yield: 74.0%

(E)-1-(4-methoxyphenyl)-3-methylbut-3-en-1-one oxime (1221447-10-4) → (+/-)-[5-methyl-3-(4-methoxyphenyl)-4,5-dihydroisoxazol-5-yl]methanol

Guidance literature:

(E)-1-(4-methoxyphenyl)-3-methylbut-3-en-1-one oxime; With 1,10-Phenanthroline; palladium diacetate; acetic acid; In water; 1,2-dichloro-ethane; at 40 ℃; under 760.051 Torr;

With potassium carbonate; In methanol; at 20 ℃; for 1h;

DOI:10.1021/ja100716x

upstream raw materials:

3-methyl-1-(4'-methoxyphenyl)-3-buten-1-ol

4-methoxy-benzaldehyde

Downstream raw materials:

5-Methyl-3-phenyl-6H-[1,2]oxazine