methyl 2-amino-5-{N-[5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)-1-benzofuran-6-yl]methanesulfonamido}benzoate

Base Information

Chemical Name:methyl 2-amino-5-{N-[5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)-1-benzofuran-6-yl]methanesulfonamido}benzoate
CAS No.:1423007-84-4
Molecular Formula:C₂₈H₂₆FN₃O₆S
Molecular Weight:551.595
Hs Code.:

Synonyms:methyl 2-amino-5-{N-[5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)-1-benzofuran-6-yl]methanesulfonamido}benzoate

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Chemical Property of methyl 2-amino-5-{N-[5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)-1-benzofuran-6-yl]methanesulfonamido}benzoate

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Technology Process of methyl 2-amino-5-{N-[5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)-1-benzofuran-6-yl]methanesulfonamido}benzoate

There total 14 articles about methyl 2-amino-5-{N-[5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)-1-benzofuran-6-yl]methanesulfonamido}benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1423007-83-3
methyl 5-{N-[5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)-1-benzofuran-6-yl]methanesulfonamido}-2-nitrobenzoate

: 1423007-84-4
methyl 2-amino-5-{N-[5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)-1-benzofuran-6-yl]methanesulfonamido}benzoate

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; for 1.5h; under 775.743 Torr; Concentration;

Reference yield:

: 393-85-1
methyl 5-fluoro-2-nitrobenzoate

: 1423007-84-4
methyl 2-amino-5-{N-[5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)-1-benzofuran-6-yl]methanesulfonamido}benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N,N,N,N,N-hexamethylphosphoric triamide / 72 h / 60 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / methanol / 1.5 h / 775.74 Torr

With palladium 10% on activated carbon; hydrogen; potassium carbonate; In methanol; N,N,N,N,N,N-hexamethylphosphoric triamide;

Reference yield:

: 691856-35-6
5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-6-(methylsulfonamido)benzofuran-3-carboxamide

: 1423007-84-4
methyl 2-amino-5-{N-[5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)-1-benzofuran-6-yl]methanesulfonamido}benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N,N,N,N,N-hexamethylphosphoric triamide / 72 h / 60 °C

2: palladium 10% on activated carbon; hydrogen / methanol / 1.5 h / 775.74 Torr

With palladium 10% on activated carbon; hydrogen; potassium carbonate; In methanol; N,N,N,N,N,N-hexamethylphosphoric triamide;