6-(Piperazin-1-yl)nicotinonitrile

Base Information

Chemical Name:6-(Piperazin-1-yl)nicotinonitrile
CAS No.:149554-29-0
Molecular Formula:C10H12N4
Molecular Weight:188.232
Hs Code.:29339900
European Community (EC) Number:673-113-1
DSSTox Substance ID:DTXSID10371899
Wikidata:Q82159421
Mol file:149554-29-0.mol

Synonyms:149554-29-0;6-(piperazin-1-yl)nicotinonitrile;6-Piperazinonicotinonitrile;6-piperazin-1-yl-nicotinonitrile;6-(Piperazin-1-Yl)Pyridine-3-Carbonitrile;6-piperazin-1-ylpyridine-3-carbonitrile;3-Pyridinecarbonitrile, 6-(1-piperazinyl)-;2-(1-Piperazino)pyridine-5-carbonitrile;6-(Piperazino)pyridine-3-carbonitrile;2-(piperazin-1-yl)-5-pyridinecarbonitrile;MFCD00833024;Maybridge3_007438;3-Pyridinecarbonitrile,6-(1-piperazinyl)-;SCHEMBL231983;6-piperazin-1-ylnicotinonitrile;DTXSID10371899;N-(5-cyano-2-pyridyl)piperazine;ZYNPMKJQFWNFMI-UHFFFAOYSA-N;HMS1452C15;GS0789;AKOS000149236;6-piperazinonicotinonitrile, AldrichCPR;AS-5473;IDI1_018825;6-Piperazin-1-yl)pyridine-3-carbonitrile;CS-0040818;FT-0621308;EN300-51534;D72681;J-008600;Z239675116

Suppliers and Price of 6-(Piperazin-1-yl)nicotinonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
6-Piperazinonicotinonitrile
250mg
$ 85.00

SynQuest Laboratories
6-(Piperazin-1-yl)nicotinonitrile 95%
5 g
$ 202.00

SynQuest Laboratories
6-(Piperazin-1-yl)nicotinonitrile 95%
1 g
$ 109.00

Matrix Scientific
6-Piperazin-1-yl-nicotinonitrile 95+%
5g
$ 284.00

Crysdot
6-(Piperazin-1-yl)nicotinonitrile 95+%
100g
$ 903.00

CHESS?
MC002840: 6-Piperazin-1-yl-nicotinonitrile 95
1 g
$ 336.00

CHESS?
2-(Piperazin-1-yl)-5-pyridinecarbonitrile >98
10 g
$ 11400.00

CHESS?
2-(Piperazin-1-yl)-5-pyridinecarbonitrile >98
2 g
$ 6000.00

Chemenu
6-Piperazin-1-yl-nicotinonitrile 95%
100g
$ 844.00

Atlantic Research Chemicals
6-Piperazin-1-ylnicotinonitrile 95%
500mgs:
$ 24.74

Total 21 raw suppliers

Chemical Property of 6-(Piperazin-1-yl)nicotinonitrile

Chemical Property:

Vapor Pressure:1.04E-06mmHg at 25°C
Melting Point:131 °C
Refractive Index:1.605
Boiling Point:403.2 °C at 760 mmHg
PKA:8.47±0.10(Predicted)
Flash Point:197.6 °C
PSA：51.95000
Density:1.22 g/cm³
LogP:0.75668
Storage Temp.:Keep in dark place,Sealed in dry,Room Temperature
XLogP3:0.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:188.106196400
Heavy Atom Count:14
Complexity:226

Purity/Quality:

99%, ^*data from raw suppliers

6-Piperazinonicotinonitrile ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi,T
Statements: 20/21/22-36/37/38-25
Safety Statements: 26-36/37/39-45-24/25-23

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN(CCN1)C2=NC=C(C=C2)C#N
Uses 6-Piperazinonicotinonitrile acts as a reagent in the synthesis and molecular docking studies of piperazine-derived constrained inhibitors of DPP-IV for treatment of type 2 Diabetes.

Technology Process of 6-(Piperazin-1-yl)nicotinonitrile

There total 4 articles about 6-(Piperazin-1-yl)nicotinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 683274-61-5
tert-butyl 4-(5-cyanopyridine-2-yl)piperazine-1-carboxylate

: 149554-29-0
6-piperazin-1-yl-nicotinonitrile

Guidance literature:: With hydrogenchloride; In 1,4-dioxane;

Reference yield:

: 110-85-0
piperazine

: 33252-28-7
6-chloronicotinonitrile

: 149554-29-0
6-piperazin-1-yl-nicotinonitrile

Guidance literature:: In acetonitrile; at 60 ℃; for 5h;

Reference yield:

: 33252-28-7
6-chloronicotinonitrile

: 149554-29-0
6-piperazin-1-yl-nicotinonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / ISOPROPYLAMIDE / 2 h / 150 °C / Microwave irradiation

2: hydrogenchloride / 1,4-dioxane

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; ISOPROPYLAMIDE;