Tert-butyl 4-(5-cyanopyridin-2-yl)piperazine-1-carboxylate

Base Information

Chemical Name:Tert-butyl 4-(5-cyanopyridin-2-yl)piperazine-1-carboxylate
CAS No.:683274-61-5
Molecular Formula:C₁₅H₂₀N₄O₂
Molecular Weight:288.349
Hs Code.:2933990090
DSSTox Substance ID:DTXSID701168226
Nikkaji Number:J3.049.868B
Mol file:683274-61-5.mol

Synonyms:Tert-butyl 4-(5-cyanopyridin-2-yl)piperazine-1-carboxylate;683274-61-5;SCHEMBL3554489;CUKYCLGXUNOINC-UHFFFAOYSA-N;DTXSID701168226;MFCD03407524;AKOS008082179;FS-5693;FT-0721201;EN300-7401489;t-butyl-4-(5-cyanopyridin-2-yl)piperazin-1-carboxylate;Z219420848;1,1-Dimethylethyl 4-(5-cyano-2-pyridinyl)-1-piperazinecarboxylate;4-(5-Cyano-2-pyridyl)piperazine-1-carboxylic acid tert-butyl ester

Suppliers and Price of Tert-butyl 4-(5-cyanopyridin-2-yl)piperazine-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
5-Cyano-2-[4-butoxycarbonyl(piperazino)]pyridine 95+%
5g
$ 583.00

AK Scientific
tert-Butyl4-(5-cyanopyridin-2-yl)piperazine-1-carboxylate
1g
$ 326.00

Total 1 raw suppliers

Chemical Property of Tert-butyl 4-(5-cyanopyridin-2-yl)piperazine-1-carboxylate

Chemical Property:

Melting Point:126-128°C
PSA：69.46000
LogP:2.01328
XLogP3:1.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:288.15862589
Heavy Atom Count:21
Complexity:415

Purity/Quality:: 5-Cyano-2-[4-butoxycarbonyl(piperazino)]pyridine 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)N1CCN(CC1)C2=NC=C(C=C2)C#N

Technology Process of Tert-butyl 4-(5-cyanopyridin-2-yl)piperazine-1-carboxylate

There total 6 articles about Tert-butyl 4-(5-cyanopyridin-2-yl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: potassiumhexacyanoferrate(II) trihydrate

: 153747-97-8
5-Bromo-2-(4-tert-butoxycarbonylpiperazin-1-yl)pyridine

: 683274-61-5
tert-butyl 4-(5-cyanopyridine-2-yl)piperazine-1-carboxylate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,8-diazabicyclo[5.4.0]undec-7-ene; In water; tert-butyl alcohol; at 85 ℃; for 4h; Inert atmosphere;
DOI:10.1039/c2cc17468e

Reference yield: 73.0%

: 33252-28-7
6-chloronicotinonitrile

: 57260-71-6
1-t-Butoxycarbonylpiperazine

: 683274-61-5
tert-butyl 4-(5-cyanopyridine-2-yl)piperazine-1-carboxylate

Guidance literature:: With potassium carbonate; In N,N-dimethyl acetamide; at 20 - 60 ℃; for 6h; Inert atmosphere;

Reference yield: 72.0%

: 557-21-1
zinc(II) cyanide

: 153747-97-8
5-Bromo-2-(4-tert-butoxycarbonylpiperazin-1-yl)pyridine

: 683274-61-5
tert-butyl 4-(5-cyanopyridine-2-yl)piperazine-1-carboxylate

Guidance literature:: 5-Bromo-2-(4-tert-butoxycarbonylpiperazin-1-yl)pyridine; With 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In N,N-dimethyl acetamide; at 45 ℃; Sealed tube; Inert atmosphere;

zinc(II) cyanide; With zinc; In N,N-dimethyl acetamide; at 100 ℃; for 26h; Sealed tube; Inert atmosphere;