cyano-[3-ethyl-4-oxo-5-[1-[3-(2-pyrrolidin-1-yl-ethyl)-phenylamino]-meth-(E/Z)-ylidene]-thiazolidin-(2-(E/Z))-ylidene]-acetic acid

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Chemical Name:cyano-[3-ethyl-4-oxo-5-[1-[3-(2-pyrrolidin-1-yl-ethyl)-phenylamino]-meth-(E/Z)-ylidene]-thiazolidin-(2-(E/Z))-ylidene]-acetic acid
CAS No.:891857-45-7
Molecular Formula:C₂₁H₂₄N₄O₃S
Molecular Weight:412.513
Hs Code.:

Synonyms:cyano-[3-ethyl-4-oxo-5-[1-[3-(2-pyrrolidin-1-yl-ethyl)-phenylamino]-meth-(E/Z)-ylidene]-thiazolidin-(2-(E/Z))-ylidene]-acetic acid

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Chemical Property of cyano-[3-ethyl-4-oxo-5-[1-[3-(2-pyrrolidin-1-yl-ethyl)-phenylamino]-meth-(E/Z)-ylidene]-thiazolidin-(2-(E/Z))-ylidene]-acetic acid

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Technology Process of cyano-[3-ethyl-4-oxo-5-[1-[3-(2-pyrrolidin-1-yl-ethyl)-phenylamino]-meth-(E/Z)-ylidene]-thiazolidin-(2-(E/Z))-ylidene]-acetic acid

There total 2 articles about cyano-[3-ethyl-4-oxo-5-[1-[3-(2-pyrrolidin-1-yl-ethyl)-phenylamino]-meth-(E/Z)-ylidene]-thiazolidin-(2-(E/Z))-ylidene]-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 891856-67-0
cyano-[3-ethyl-4-oxo-5-[1-[3-(2-pyrrolidin-1-yl-ethyl)-phenylamino]-meth-(E/Z)-ylidene]-thiazolidin-(2-(E/Z))-ylidene]-acetic acid allyl ester

: 891857-45-7
cyano-[3-ethyl-4-oxo-5-[1-[3-(2-pyrrolidin-1-yl-ethyl)-phenylamino]-meth-(E/Z)-ylidene]-thiazolidin-(2-(E/Z))-ylidene]-acetic acid

Guidance literature:: cyano-[3-ethyl-4-oxo-5-[1-[3-(2-pyrrolidin-1-yl-ethyl)-phenylamino]-meth-(E/Z)-ylidene]-thiazolidin-(2-(E/Z))-ylidene]-acetic acid allyl ester; With morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; for 15h;

With PL-MIA resin; In N,N-dimethyl-formamide; at 20 ℃; for 15h; Product distribution / selectivity;

Reference yield:

: 891856-66-9
cyano-[3-ethyl-4-oxo-5-[1-[3-(2-pyrrolidin-1-yl-ethyl)-phenylamino]-meth-(E/Z)-ylidene]-thiazolidin-(2-(E/Z))-ylidene]-acetic acid ethyl ester

: 891857-45-7
cyano-[3-ethyl-4-oxo-5-[1-[3-(2-pyrrolidin-1-yl-ethyl)-phenylamino]-meth-(E/Z)-ylidene]-thiazolidin-(2-(E/Z))-ylidene]-acetic acid

Guidance literature:: cyano-[3-ethyl-4-oxo-5-[1-[3-(2-pyrrolidin-1-yl-ethyl)-phenylamino]-meth-(E/Z)-ylidene]-thiazolidin-(2-(E/Z))-ylidene]-acetic acid ethyl ester; With potassium tert-butylate; water; In tetrahydrofuran; at 0 - 20 ℃; for 20.5h;

With hydrogenchloride; triethylamine; In tetrahydrofuran; diethyl ether; at 0 - 20 ℃; for 1h; Product distribution / selectivity;

Reference yield:

: 891857-45-7
cyano-[3-ethyl-4-oxo-5-[1-[3-(2-pyrrolidin-1-yl-ethyl)-phenylamino]-meth-(E/Z)-ylidene]-thiazolidin-(2-(E/Z))-ylidene]-acetic acid

: 124-68-5
2-Amino-2-methyl-1-propanol

: 2-cyano-2-[3-ethyl-4-oxo-5-[1-[3-(2-pyrrolidin-1-ylethyl)-phenylamino]-meth-(Z)-ylidene]-thiazolidin-2-ylidene]-N-(2-hydroxy-1,1-dimethyl-ethyl)-acetamide

: 2-cyano-2-[3-ethyl-4-oxo-5-[1-[3-(2-pyrrolidin-1-ylethyl)-phenylamino]-meth-(E)-ylidene]-thiazolidin-2-ylidene]-N-(2-hydroxy-1,1-dimethyl-ethyl)-acetamide

Guidance literature:: With sodium hydrogencarbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; In N,N-dimethyl-formamide; at 20 ℃; for 18h;