2-Hydroxy-6-(2-thienyl)-4-(trifluoromethyl)nicotinonitrile

Base Information

• Chemical Name: 2-Hydroxy-6-(2-thienyl)-4-(trifluoromethyl)nicotinonitrile
• CAS No.: 22123-11-1
• Molecular Formula: C11H5F3N2OS
• Molecular Weight: 270.23
• Hs Code.: 2934999090
• European Community (EC) Number: 809-111-6
• DSSTox Substance ID: DTXSID40351341
• ChEMBL ID: CHEMBL3627736
• Mol file: 22123-11-1.mol

Synonyms:3335-45-3;22123-11-1;2-hydroxy-6-(2-thienyl)-4-(trifluoromethyl)nicotinonitrile;2-Oxo-6-thiophen-2-yl-4-trifluoromethyl-1,2-dihydropyridine-3-carbonitrile;2-oxo-6-(thiophen-2-yl)-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile;2-Hydroxy-6-(thiophen-2-yl)-4-(trifluoromethyl)nicotinonitrile;2-oxo-6-thiophen-2-yl-4-(trifluoromethyl)-1H-pyridine-3-carbonitrile;CHEMBL3627736;MFCD00741364;2-oxo-6-(2-thienyl)-4-(trifluoromethyl)-1,2-dihydro-3-pyridinecarbonitrile;2-Hydroxy-6-(thien-2-yl)-4-(trifluoromethyl)pyridine-3-carbonitrile;3-cyano-6-(2-thienyl)-4-trifluoromethyl-2(1h)-pyridone;Maybridge1_006155;2-HYDROXY-6-THIEN-2-YL-4-(TRIFLUOROMETHYL)PYRIDINE-3-CARBONITRILE;HMS558P17;2-Hydroxy-6-(2-thienyl)-4-trifluoromethyl nicotinonitrile;DTXSID40351341;CHEBI:194820;UBBGOCKMIMCHLZ-UHFFFAOYSA-N;BDBM50129066;MFCD00052654;STK053367;2-hydroxy-6-(thiophen-2-yl)-4-(trifluoromethyl)pyridine-3-carbonitrile;AKOS000487342;AKOS005083838;2K-305S;SB55372;CS-0320666;FT-0612561;FT-0638191;1T-0036;3-cyano-6-(2-thienyl)-4-trifluoromethyl pyridone;A815946;SR-01000507121;J-014528;SR-01000507121-1;3-cyano-4-trifluoromethyl-6-(2-thienyl)-1h-pyridone;F0903-0102;3-Cyano-4-trifluoromethyl-6-(2-thienyl)-2(1H)-pyridone;2-Hydroxy-6-(2-thienyl)-4-(trifluoromethyl)-nicotinonitrile;2-Hydroxy-6-(2-thienyl)-4-trifluoromethyl nicotinonitrile, AldrichCPR;2-Hydroxy-6-(thien-2-yl)-4-(trifluoromethyl)pyridine-3-carbonitrile 97%;2-oxo-6-thiophen-2-yl-4-(triluoromethyl)-1H-pyridine-3-carbonitrile;4-(trifluoromethyl)-1,2-dihydro-2-oxo-6-(thiophen-2-yl)pyridine-3-carbonitrile;2-oxo-6-(2-thienyl)-4-(trifluoromethyl)-1H-pyridine-3-carbonitrile;2-Oxo-6-(thiophen-2-yl)-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile

Chemical Property of 2-Hydroxy-6-(2-thienyl)-4-(trifluoromethyl)nicotinonitrile

Chemical Property:

• Vapor Pressure: 2.7E-06mmHg at 25°C
• Refractive Index: 1.574
• Boiling Point: 390.2 °C at 760 mmHg
• PKA: 8.87±0.10(Predicted)
• Flash Point: 189.8 °C
• PSA: 84.89000
• Density: 1.52 g/cm³
• LogP: 2.99388
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 1
• Exact Mass: 270.00746845
• Heavy Atom Count: 18
• Complexity: 498

Purity/Quality:

97% ^*data from raw suppliers

2-Hydroxy-6-(2-thienyl)-4-trifluoromethyl nicotinonitrile AldrichCPR ^*data from reagent suppliers

Safty Information:

• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CSC(=C1)C2=CC(=C(C(=O)N2)C#N)C(F)(F)F

Technology Process of 2-Hydroxy-6-(2-thienyl)-4-(trifluoromethyl)nicotinonitrile

There total 1 articles about 2-Hydroxy-6-(2-thienyl)-4-(trifluoromethyl)nicotinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-oxo-6-(thiophen-2-yl)-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile (3335-45-3) → 6-thiophen-2-yl-4-(trifluoromethyl)pyridine-2(1H)-one (22123-11-1)

Guidance literature:

With sulfuric acid; at 148 ℃; for 10h;

Reference yield:

6-thiophen-2-yl-4-(trifluoromethyl)pyridine-2(1H)-one (22123-11-1) → N-benzyl-4-oxo-6-(thiophen-2-yl)-8-(trifluoromethyl)-4H-pyrido[1,2-a]pyrimidine-3-carboxamide

Guidance literature:

Multi-step reaction with 4 steps

1: Chloroacetamide; sodium iodide; potassium carbonate / Reflux

2: ethanol / 10 h / Reflux

3: trichlorophosphate / 0.25 h / 150 °C / Microwave irradiation

4: 6 h / Sealed tube; Reflux

With potassium carbonate; sodium iodide; Chloroacetamide; trichlorophosphate; In ethanol; 1: |Smiles Aromatic Rearrangement;

DOI:10.1248/cpb.c15-00219

Reference yield:

6-thiophen-2-yl-4-(trifluoromethyl)pyridine-2(1H)-one (22123-11-1) → N-(4-methylbenzyl)-4-oxo-6-(thiophen-2-yl)-8-(trifluoromethyl)-4H-pyrido[1,2-a]pyrimidine-3-carboxamide

Guidance literature:

Multi-step reaction with 4 steps

1: Chloroacetamide; sodium iodide; potassium carbonate / Reflux

2: ethanol / 10 h / Reflux

3: trichlorophosphate / 0.25 h / 150 °C / Microwave irradiation

4: 6 h / Sealed tube; Reflux

With potassium carbonate; sodium iodide; Chloroacetamide; trichlorophosphate; In ethanol; 1: |Smiles Aromatic Rearrangement;

DOI:10.1248/cpb.c15-00219

upstream raw materials:

2-oxo-6-(thiophen-2-yl)-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 22123-11-1 3-Cyano-6-(2-thienyl)-4-trifluoromethyl-2(1H)-pyridone

Send

Send

Metric Ton KG G Pound L ML

Send

Send