4-[4-(2,6-difluorophenoxymethyl)thiophen-3-yl]piperidine trifluoroacetate

Base Information

Chemical Name:4-[4-(2,6-difluorophenoxymethyl)thiophen-3-yl]piperidine trifluoroacetate
CAS No.:1334393-52-0
Molecular Formula:C₂HF₃O₂*C₁₆H₁₇F₂NOS
Molecular Weight:423.404
Hs Code.:

Synonyms:4-[4-(2,6-difluorophenoxymethyl)thiophen-3-yl]piperidine trifluoroacetate

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Chemical Property of 4-[4-(2,6-difluorophenoxymethyl)thiophen-3-yl]piperidine trifluoroacetate

Chemical Property:

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Technology Process of 4-[4-(2,6-difluorophenoxymethyl)thiophen-3-yl]piperidine trifluoroacetate

There total 6 articles about 4-[4-(2,6-difluorophenoxymethyl)thiophen-3-yl]piperidine trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 28177-48-2
2,6-difluorophenol

: 1334394-49-8
4-(4-hydroxymethylthiophen-3-yl)piperidine-1-carboxylic acid t-butyl ester

: 76-05-1
trifluoroacetic acid

: 1334393-52-0
4-[4-(2,6-difluorophenoxymethyl)thiophen-3-yl]piperidine trifluoroacetate

Guidance literature:: 2,6-difluorophenol; 4-(4-hydroxymethylthiophen-3-yl)piperidine-1-carboxylic acid t-butyl ester; With di-isopropyl azodicarboxylate; triphenylphosphine; In toluene; at 80 ℃; for 4h;

With hydrogenchloride; In ethanol; at 20 ℃;

trifluoroacetic acid;

Reference yield:

: 375853-82-0,286961-14-6
tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-1(2H)-pyridinecarboxylate

: 1334393-52-0
4-[4-(2,6-difluorophenoxymethyl)thiophen-3-yl]piperidine trifluoroacetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 18 h / Inert atmosphere; Reflux

2.1: hydrogen / 10 wt% Pd(OH)2 on carbon / ethyl acetate; methanol / 36 h / 20 - 40 °C / 760.05 Torr

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 - 5 °C / Inert atmosphere

4.1: triphenylphosphine; di-isopropyl azodicarboxylate / toluene / 4 h / 80 °C

4.2: 20 °C

With lithium aluminium tetrahydride; di-isopropyl azodicarboxylate; hydrogen; sodium carbonate; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride; 10 wt% Pd(OH)2 on carbon; In tetrahydrofuran; methanol; ethyl acetate; toluene;

Reference yield:

: 138647-49-1
4-Trifluoromethanesulfonyloxy-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

: 1334393-52-0
4-[4-(2,6-difluorophenoxymethyl)thiophen-3-yl]piperidine trifluoroacetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium acetate / 1,1'-bis-(diphenylphosphino)ferrocene; 1,1'-bis(diphenylphosphino)ferrocene-palladium(ii)dichloride-chloroform adduct / 1,4-dioxane / 80 °C / Inert atmosphere

2.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 18 h / Inert atmosphere; Reflux

3.1: hydrogen / 10 wt% Pd(OH)2 on carbon / ethyl acetate; methanol / 36 h / 20 - 40 °C / 760.05 Torr

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 - 5 °C / Inert atmosphere

5.1: triphenylphosphine; di-isopropyl azodicarboxylate / toluene / 4 h / 80 °C

5.2: 20 °C

With lithium aluminium tetrahydride; di-isopropyl azodicarboxylate; hydrogen; potassium acetate; sodium carbonate; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride; 1,1'-bis-(diphenylphosphino)ferrocene; 1,1'-bis(diphenylphosphino)ferrocene-palladium(ii)dichloride-chloroform adduct; 10 wt% Pd(OH)2 on carbon; In tetrahydrofuran; 1,4-dioxane; methanol; ethyl acetate; toluene;