(E)-2-[2-isopropyl-4-methyl-5-(3-oxobut-1-enyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-4-methylpentanoic acid cyclohexylamide

Base Information

Chemical Name:(E)-2-[2-isopropyl-4-methyl-5-(3-oxobut-1-enyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-4-methylpentanoic acid cyclohexylamide
CAS No.:1272662-56-2
Molecular Formula:C₂₆H₃₈N₄O₂
Molecular Weight:438.613
Hs Code.:

Synonyms:(E)-2-[2-isopropyl-4-methyl-5-(3-oxobut-1-enyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-4-methylpentanoic acid cyclohexylamide

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Chemical Property of (E)-2-[2-isopropyl-4-methyl-5-(3-oxobut-1-enyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-4-methylpentanoic acid cyclohexylamide

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Technology Process of (E)-2-[2-isopropyl-4-methyl-5-(3-oxobut-1-enyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-4-methylpentanoic acid cyclohexylamide

There total 3 articles about (E)-2-[2-isopropyl-4-methyl-5-(3-oxobut-1-enyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-4-methylpentanoic acid cyclohexylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1272662-46-0
N-cyclohexyl-2-((5-iodo-2-isopropyl-6-methylpyrimidin-4-yl)((5-methylfuran-2-yl)methyl)amino)-4-methylpentanamide

: 1272662-56-2
(E)-2-[2-isopropyl-4-methyl-5-(3-oxobut-1-enyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-4-methylpentanoic acid cyclohexylamide

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 130 ℃; for 0.333333h; under 9750.98 Torr; Microwave irradiation;
DOI:10.1039/c0cc04164e

Reference yield:

: 2814-20-2
2-isopropyl-6-methyl-4-pyrimidinol

: 1272662-56-2
(E)-2-[2-isopropyl-4-methyl-5-(3-oxobut-1-enyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-4-methylpentanoic acid cyclohexylamide

Guidance literature:: Multi-step reaction with 3 steps

1: iodine; potassium carbonate / tetrahydrofuran / Reflux

2: methanol / 72 h / 60 °C

3: bis-triphenylphosphine-palladium(II) chloride; N-ethyl-N,N-diisopropylamine / acetonitrile / 0.33 h / 130 °C / 9750.98 Torr / Microwave irradiation

With bis-triphenylphosphine-palladium(II) chloride; iodine; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; acetonitrile; 2: Ugi condensation;
DOI:10.1039/c0cc04164e

Reference yield:

: 14003-16-8
5-methylfurfurylamine

: 931-53-3
Cyclohexyl isocyanide

: 69696-38-4
5-iodo-2-isopropyl-6-methyl-pyrimidin-4-ol

: 590-86-3
isovaleraldehyde

: 1272662-56-2
(E)-2-[2-isopropyl-4-methyl-5-(3-oxobut-1-enyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-4-methylpentanoic acid cyclohexylamide

Guidance literature:: Multi-step reaction with 2 steps

1: methanol / 72 h / 60 °C

2: bis-triphenylphosphine-palladium(II) chloride; N-ethyl-N,N-diisopropylamine / acetonitrile / 0.33 h / 130 °C / 9750.98 Torr / Microwave irradiation

With bis-triphenylphosphine-palladium(II) chloride; N-ethyl-N,N-diisopropylamine; In methanol; acetonitrile; 1: Ugi condensation;
DOI:10.1039/c0cc04164e