2814-20-2

Basic information

• Product Name: 2-ISOPROPYL-6-METHYL-4-PYRIMIDINOL
• Synonyms: 2-isopropyl-6-methyl-4(1h)-pyrimidinon;2-isopropyl-6-methyl-4(3h)-pyrimidinon;2-isopropyl-6-methyl-4-pyrimidone;6-methyl-2-(1-methylethyl)-4(1h)-pyrimidinon;6-pyrimidinol,2-isopropyl-4-methyl;g27550;imhp;TIMTEC-BB SBB009916
• CAS NO: 2814-20-2
• Molecular Formula: C₈H₁₂N₂O
• Molecular Weight: 152.19
• EINECS: 220-561-7
• Product Categories: Heterocyclic Compounds;Pyrimidines;Building Blocks;Heterocyclic Building Blocks;Alpha sort;Alphabetic;H-MAnalytical Standards;IEnvironmental Standards;Metabolites;Pesticides&Metabolites
• Mol File: 2814-20-2.mol
• Article Data: 11

Chemical Properties

• Melting Point: 172-175 °C(lit.)
• Boiling Point: 274.67°C (rough estimate)
• Flash Point: 93.2°C
• Appearance: /
• Density: 1.0996 (rough estimate)
• Vapor Pressure: 0.0655mmHg at 25°C
• Refractive Index: 1.4940 (estimate)
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 9.74±0.50(Predicted)
• CAS DataBase Reference: 2-ISOPROPYL-6-METHYL-4-PYRIMIDINOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-ISOPROPYL-6-METHYL-4-PYRIMIDINOL(2814-20-2)
• EPA Substance Registry System: 2-ISOPROPYL-6-METHYL-4-PYRIMIDINOL(2814-20-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 2
• RTECS: UW7525000
• Hazardous Substances Data: 2814-20-2(Hazardous Substances Data)

Usage

Uses

2-Isopropyl-6-methyl-4-pyrimidone, is an intermediate used for the synthesis of various benzophenone derivatives, having antifungal and antibacterial activities. It can also be used for the synthesis of Diazinon (D416880), and Diazoxon (D416890), the organophosphate insecticides.

General Description

2-Isopropyl-6-methyl-4-pyrimidinol is a pyrimidine compound. It is reported as an major metabolite of pesticide diazinon., It has been identified as urinary metabolite in the general population exposed to organophosphorus compounds (insecticides, flame retardants and plasticizers) and moth repellents used in Japanese households. Photocatalytic oxidation of 2-isopropyl-6-methyl-4-pyrimidinol has been reported.

InChI:InChI=1/C8H12N2O/c1-5(2)8-9-6(3)4-7(11)10-8/h4-5H,1-3H3,(H,9,10,11)

Upstream product

• 408308-92-9 2-(β,β'-dipiperidino-isopropyl)-6-methyl-3H-pyrimidin-4-one 
• 57536-10-4 isobutyramidine 
• 78-82-0 Isobutyronitrile 
• 64163-94-6 β-aminocrotonamide 
• 333-41-5 `Diazinon` 
• 67-56-1 methanol 
• 6622-92-0 2,6-dimethyl-1H-pyrimidin-4-one 
• 77831-93-7 2-Isopropyl-6-methyl-[1,3]thiazin-4-one 
• 87268-60-8 3-Ethyl-2-isopropyl-6-methyl-3H-pyrimidin-4-one 
• 77831-94-8 2-Isopropylidene-6-methyl-2,3-dihydro-[1,3]thiazin-4-one 
• 87268-59-5 N-Methyl-2-isopropyl-4-methyl-pyrimidine-6-one 
• 22007-68-7 2-methylpropanimidamide hydrochloride 
• 141-97-9 ethyl acetoacetate 

Downstream Products

• 105459-46-9 Benzoic acid 2-isopropyl-6-methyl-pyrimidin-4-yl ester 
• 72799-31-6 4-ethoxy-2-isopropyl-6-methyl-pyrimidine 
• 87268-60-8 3-Ethyl-2-isopropyl-6-methyl-3H-pyrimidin-4-one 
• 69696-38-4 5-Iodo-2-isopropyl-6-methyl-4(3H)-pyrimidinone 
• 333-41-5 `Diazinon` 
• 1262749-05-2 C₂₁H₂₉ClN₄O 
• 1372134-90-1 8-benzyl-2-isopropyl-4-methyl-5,8-dihydropyrido[2,3-d]pyrimidine 
• 1372134-88-7 N-benzyl-N-cyclopropyl-5-iodo-2-isopropyl-6-methylpyrimidin-4-amine 
• 1372134-75-2 2-(2-isopropyl-4-methyl-6-phenylpyrido[2,3-d]pyrimidin-8(5H)-yl)-N-(4-methoxybenzyl)acetamide 
• 1372134-72-9 N-(4-chlorobenzyl)-2-(2-isopropyl-4-methylpyrido[2,3-d]pyrimidin-8(5H)-yl)acetamide 
• 1372134-65-0 N-(4-chlorobenzyl)-2-(cyclopropyl(5-iodo-2-isopropyl-6-methylpyrimidin-4-yl)amino)acetamide 
• 1313407-24-7 2-isopropyl-6-methylpyrimidin-4-yl-3,4,5-trimethoxybenzoate 
• 1313407-20-3 2-isopropyl-6-methyl-N-(4-(trifluoromethoxy)phenyl)pyrimidin-4-amine 
• 1313407-19-0 2-isopropyl-6-methyl-N-phenylpyrimidin-4-amine 

Relevant articles and documents

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SUPPORTED MOLYBDENUM PEROXO COMPLEXES FOR TRANSFORMING ORGANO PHOSPHATE NEUROTOXINS TO A VALUE-ADDED, COMMODITY PHOSPHORUS CHEMICAL

The invention relates to degradation of organophosphate neurotoxins with molybdenum complexes. In particular, the degradation of phosphate ester neurotoxins can be performed with molybdenum peroxo complexes resulting in recoverable phosphorus-containing compounds.

Influence of Natural Dissolved Organic Matter, Temperature, and Mixing on the Abiotic Hydrolysis of Triazine and Organophosphate Pesticides

Abiotic hydrolysis of simazine, atrazine, diazinon, methylparathion, and chlorpyrifos was studied in three different natural waters and buffered Milli-Q water. The triazines showed no detectable decrease in concentration in any of the waters over 43 days at pH 8.0 and 40 °C. The rates of hydrolysis for diazinon and methylparathion were statistically similar in all waters tested. Chlorpyrifos exhibited a ～32% decrease in hydrolysis rate in the presence of a high concentration of dissolved organic matter (DOM) (34.5 mg/L dissolved organic carbon). The activation energies are larger, and thus the predicted hydrolysis rates are significantly slower than those previously reported. The effect of continuous vigorous mixing on hydrolysis rates was investigated and found to have only a minor effect. The results suggest that uncatalyzed abiotic hydrolysis is very slow for these compounds at the temperatures and pH's typical of most natural waters and affirm the need for a greater understanding of the relative influence of DOM, catalysis, and biodegradation on the fate of organophosphate and triazine pesticides.