Technology Process of (R)-2-(3,4-dichlorophenyl)-2-methylpent-4-enoic acid 2-trimethylsilanylethyl ester
There total 6 articles about (R)-2-(3,4-dichlorophenyl)-2-methylpent-4-enoic acid 2-trimethylsilanylethyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
pyridine; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
tetrahydrofuran;
at 40 ℃;
for 18h;
Inert atmosphere;
DOI:10.1021/ml400528y
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: lithium hexamethyldisilazane / tetrahydrofuran; pentane / 2 h / -25 °C / Inert atmosphere
1.2: 1.27 h / -25 - 20 °C / Inert atmosphere
2.1: thionyl chloride / 11.33 h / 20 °C / Inert atmosphere; Cooling with ice
3.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide; mineral oil / 5 h / 0 - 20 °C / Inert atmosphere
3.2: 2 h / 20 °C / Inert atmosphere
4.1: lithium hydroxide; water / methanol / 10 h / Reflux
5.1: ethyl acetate / Resolution of racemate; Inert atmosphere
6.1: hydrogenchloride / ethyl acetate; water
7.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap; pyridine / tetrahydrofuran / 18 h / 40 °C / Inert atmosphere
With
pyridine; hydrogenchloride; dmap; thionyl chloride; water; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; lithium hexamethyldisilazane;
In
tetrahydrofuran; methanol; water; ethyl acetate; N,N-dimethyl-formamide; mineral oil; pentane;
DOI:10.1021/ml400528y
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide; mineral oil / 5 h / 0 - 20 °C / Inert atmosphere
1.2: 2 h / 20 °C / Inert atmosphere
2.1: lithium hydroxide; water / methanol / 10 h / Reflux
3.1: ethyl acetate / Resolution of racemate; Inert atmosphere
4.1: hydrogenchloride / ethyl acetate; water
5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap; pyridine / tetrahydrofuran / 18 h / 40 °C / Inert atmosphere
With
pyridine; hydrogenchloride; dmap; water; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide;
In
tetrahydrofuran; methanol; water; ethyl acetate; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/ml400528y
