methyl (2S)-2-{[(benzyloxy)carbonyl]amino}-3-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}propanoate

Base Information

Chemical Name:methyl (2S)-2-{[(benzyloxy)carbonyl]amino}-3-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}propanoate
CAS No.:1333506-16-3
Molecular Formula:C₂₇H₂₆N₂O₆
Molecular Weight:474.513
Hs Code.:

Synonyms:methyl (2S)-2-{[(benzyloxy)carbonyl]amino}-3-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}propanoate

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Chemical Property of methyl (2S)-2-{[(benzyloxy)carbonyl]amino}-3-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}propanoate

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Technology Process of methyl (2S)-2-{[(benzyloxy)carbonyl]amino}-3-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}propanoate

There total 5 articles about methyl (2S)-2-{[(benzyloxy)carbonyl]amino}-3-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 75760-11-1
(S)-methyl 3-amino-2-(((benzyloxy)carbonyl)amino)propanoate

: 28920-43-6
(fluorenylmethoxy)carbonyl chloride

: 1333506-16-3
methyl (2S)-2-{[(benzyloxy)carbonyl]amino}-3-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}propanoate

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 3h; Inert atmosphere;
DOI:10.1002/hlca.201100013

Reference yield:

: C₄H₃OCH(NHCO₂CH₂C₆H₅)SO₂C₆H₄CH₃

: 1333506-16-3
methyl (2S)-2-{[(benzyloxy)carbonyl]amino}-3-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}propanoate

Guidance literature:: Multi-step reaction with 5 steps

1: cesium hydroxide; N-benzylcinchonidinum chloride / toluene / 40 h / -55 °C / Inert atmosphere

2: sodium periodate; ruthenium trichloride; sodium hydrogencarbonate / tetrachloromethane; water; acetonitrile / 0.17 h / 0 °C / Inert atmosphere

3: diethyl ether; dichloromethane; benzene / 3 h / 0 - 20 °C / Inert atmosphere

4: sodium tetrahydroborate; nickel dichloride / methanol / 0.42 h / -5 °C / Inert atmosphere

5: triethylamine / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

With ruthenium trichloride; sodium tetrahydroborate; sodium periodate; cesium hydroxide; sodium hydrogencarbonate; triethylamine; N-benzylcinchonidinum chloride; nickel dichloride; In methanol; tetrachloromethane; diethyl ether; dichloromethane; water; toluene; acetonitrile; benzene; 1: Aza-Henry reaction;
DOI:10.1002/hlca.201100013

Reference yield:

: 1333506-14-1
benzyl N-[(1S)-1-(furan-2-yl)-2-nitroethyl]carbamate

: 1333506-16-3
methyl (2S)-2-{[(benzyloxy)carbonyl]amino}-3-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}propanoate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium periodate; ruthenium trichloride; sodium hydrogencarbonate / tetrachloromethane; water; acetonitrile / 0.17 h / 0 °C / Inert atmosphere

2: diethyl ether; dichloromethane; benzene / 3 h / 0 - 20 °C / Inert atmosphere

3: sodium tetrahydroborate; nickel dichloride / methanol / 0.42 h / -5 °C / Inert atmosphere

4: triethylamine / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

With ruthenium trichloride; sodium tetrahydroborate; sodium periodate; sodium hydrogencarbonate; triethylamine; nickel dichloride; In methanol; tetrachloromethane; diethyl ether; dichloromethane; water; acetonitrile; benzene;
DOI:10.1002/hlca.201100013