7,7-dimethyl 4-(3-nitrophenyl)-4,6,7,8-tetrahydro-1H,3H-quinazoline-2,5-dione

Base Information

• Chemical Name: 7,7-dimethyl 4-(3-nitrophenyl)-4,6,7,8-tetrahydro-1H,3H-quinazoline-2,5-dione
• CAS No.: 301676-39-1
• Molecular Formula: C₁₆H₁₇N₃O₄
• Molecular Weight: 315.329

Synonyms:7,7-dimethyl 4-(3-nitrophenyl)-4,6,7,8-tetrahydro-1H,3H-quinazoline-2,5-dione

Chemical Property of 7,7-dimethyl 4-(3-nitrophenyl)-4,6,7,8-tetrahydro-1H,3H-quinazoline-2,5-dione

Chemical Property:

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Technology Process of 7,7-dimethyl 4-(3-nitrophenyl)-4,6,7,8-tetrahydro-1H,3H-quinazoline-2,5-dione

There total 1 articles about 7,7-dimethyl 4-(3-nitrophenyl)-4,6,7,8-tetrahydro-1H,3H-quinazoline-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

3-nitro-benzaldehyde (99-61-6) + dimedone (126-81-8) + urea (57-13-6) → 7,7-dimethyl 4-(3-nitrophenyl)-4,6,7,8-tetrahydro-1H,3H-quinazoline-2,5-dione (301676-39-1)

Guidance literature:

With Poly(ethylene glycol)perchloric acid; In neat (no solvent); at 70 ℃; for 0.0833333h; Green chemistry;

DOI:10.1039/c3ra44685a

Reference yield: 80.0%

7,7-dimethyl 4-(3-nitrophenyl)-4,6,7,8-tetrahydro-1H,3H-quinazoline-2,5-dione (301676-39-1) + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → 3-(2-methoxycarbonyl-ethyl)-4-(3-nitrophenyl)-7,7-dimethyl-1,2,3,4,5,6,7,8-octahydroquinazoline-2,5-dione

Guidance literature:

With KF/Al₂O₃; In N,N-dimethyl-formamide; at 40 ℃; for 12h; regioselective reaction;

DOI:10.3184/174751911X13129294387591

Reference yield: 39.0%

styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) + glyoxylic acid ethyl ester (924-44-7) + 7,7-dimethyl 4-(3-nitrophenyl)-4,6,7,8-tetrahydro-1H,3H-quinazoline-2,5-dione (301676-39-1) → (E)-ethyl 2-(7,7-dimethyl-4-(3-nitrophenyl)-2,5-dioxo-1,2,5,6,7,8-hexahydroquinazolin-3(4H)-yl)-4-phenyl-3-butenoate + ethyl 2-(7,7-dimethyl-4-(3-nitrophenyl)-2,5-dioxo-1,2,5,6,7,8-hexahydroquinazolin-3 (4H)-yl)acetate

Guidance literature:

With iodine; In 1,4-dioxane; at 110 ℃; for 36h;

DOI:10.1016/j.tet.2014.10.006

upstream raw materials:

3-nitro-benzaldehyde

dimedone

urea

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