3-TRIFLUOROMETHYL-4'-METHOXYDIPHENYLAMINE

Base Information

• Chemical Name: 3-TRIFLUOROMETHYL-4'-METHOXYDIPHENYLAMINE
• CAS No.: 1494-26-4
• Molecular Formula: C14H12 F3 N O
• Molecular Weight: 267.251
• Hs Code.: 2922199090
• Mol file: 1494-26-4.mol

Synonyms:p-Anisidine,N-(a,a,a-trifluoro-m-tolyl)- (8CI); 3-Trifluoromethyl-4'-methoxydiphenylamine;4-Methoxy-3'-(trifluoromethyl)diphenylamine

Chemical Property of 3-TRIFLUOROMETHYL-4'-METHOXYDIPHENYLAMINE

Chemical Property:

• Melting Point: 58 °C
• Boiling Point: 330.7°Cat760mmHg
• PKA: 0.33±0.50(Predicted)
• Flash Point: 153.8°C
• PSA: 21.26000
• Density: 1.254g/cm³
• LogP: 4.53060
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility.: almost transparency in Methanol

Purity/Quality:

97% ^*data from raw suppliers

3-Trifluoromethyl-4''-methoxydiphenylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn,C,Xi
• Hazard Codes: Xn,C,Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-TRIFLUOROMETHYL-4'-METHOXYDIPHENYLAMINE

There total 7 articles about 3-TRIFLUOROMETHYL-4'-METHOXYDIPHENYLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-chloromethoxybenzene (623-12-1) + 3-trifluoromethylaniline (98-16-8) → N-(4-methoxyphenyl)-N-(3-trifluoromethylphenyl)amine (1494-26-4)

Guidance literature:

With C₅₀H₇₂ClPPd; 2,6-bis(2,4,6-triisopropylphenyl)phenyldicyclohexylphosphine; sodium t-butanolate; In 1,4-dioxane; at 100 ℃; for 1h; Reagent/catalyst; Solvent;

DOI:10.1016/j.jcat.2021.08.017

Reference yield: 91.0%

→ N-(4-methoxyphenyl)-N-(3-trifluoromethylphenyl)amine (1494-26-4)

Guidance literature:

With C₅₀H₇₉ClN₂O₄Pd; potassium 2-methylbutan-2-olate; In toluene; at 80 - 110 ℃; for 9h;

Reference yield: 89.0%

3-trifluoromethylnitrobenzene (98-46-4) + 4-methoxyphenylboronic acid (5720-07-0) → N-(4-methoxyphenyl)-N-(3-trifluoromethylphenyl)amine (1494-26-4) + 3-trifluoromethylaniline (98-16-8)

Guidance literature:

With phenylsilane; copper diacetate; 1,4-di(diphenylphosphino)-butane; In toluene; acetonitrile; at 60 ℃; for 30h;

DOI:10.1021/acscatal.1c03113

upstream raw materials:

4-chloromethoxybenzene

3-trifluoromethylaniline

m-trifluoromethylphenyl iodide

4-methoxy-aniline

Downstream raw materials:

N,N'-bis (3-trifluoromethylphenyl)-N,N'-bis (4-methoxyphenyl)-(1,1'-biphenyl)-4,4'-diamine

N-(4-methoxyphenyl)-N-p-tolyl-3-(trifluoromethyl)aniline

N,N-bis(4-methoxyphenyl)-3-(trifluoromethyl)aniline

N-(4-methoxyphenyl)-2,6-dimethyl-N-(3-(trifluoromethyl)phenyl)aniline