methyl 4-(3-(quinolin-6-ylmethyl)-3H-[1,2,3]-triazolo[4,5-b]pyridin-5-yl)benzoate

Base Information

Chemical Name:methyl 4-(3-(quinolin-6-ylmethyl)-3H-[1,2,3]-triazolo[4,5-b]pyridin-5-yl)benzoate
CAS No.:1350426-27-5
Molecular Formula:C₂₃H₁₇N₅O₂
Molecular Weight:395.42
Hs Code.:

Synonyms:methyl 4-(3-(quinolin-6-ylmethyl)-3H-[1,2,3]-triazolo[4,5-b]pyridin-5-yl)benzoate

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Chemical Property of methyl 4-(3-(quinolin-6-ylmethyl)-3H-[1,2,3]-triazolo[4,5-b]pyridin-5-yl)benzoate

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Technology Process of methyl 4-(3-(quinolin-6-ylmethyl)-3H-[1,2,3]-triazolo[4,5-b]pyridin-5-yl)benzoate

There total 10 articles about methyl 4-(3-(quinolin-6-ylmethyl)-3H-[1,2,3]-triazolo[4,5-b]pyridin-5-yl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 1313726-84-9
6-((5-chloro-3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)methyl)quinoline

: 99768-12-4
4-methoxycarbonylphenylboronic acid

: 1350426-27-5
methyl 4-(3-(quinolin-6-ylmethyl)-3H-[1,2,3]-triazolo[4,5-b]pyridin-5-yl)benzoate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; water; at 20 ℃; Inert atmosphere; Reflux;

Reference yield: 57.0%

: 1350426-27-5
methyl 4-(3-(quinolin-6-ylmethyl)-3H-[1,2,3]-triazolo[4,5-b]pyridin-5-yl)benzoate

Guidance literature:

Reference yield:

: 5382-43-4
quinoline-6-carboxamide

: 1350426-27-5
methyl 4-(3-(quinolin-6-ylmethyl)-3H-[1,2,3]-triazolo[4,5-b]pyridin-5-yl)benzoate

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine; trifluoroacetic anhydride / chloroform / 1.5 h / 10 °C

2: ammonia; hydrogen / methanol / 16 h / 20 °C / 760.05 Torr

3: sodium carbonate / ethanol / 12 h / 0 - 20 °C

4: tin(ll) chloride; hydrogenchloride / water / 2 h / 20 °C

5: acetic acid; sodium nitrite; sulfuric acid / water / 0.5 h / 20 °C

6: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 20 °C / Inert atmosphere; Reflux

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; ammonia; hydrogen; sodium carbonate; potassium carbonate; acetic acid; triethylamine; trifluoroacetic anhydride; tin(ll) chloride; sodium nitrite; In 1,4-dioxane; methanol; ethanol; chloroform; water;