5382-43-4

Basic information

• Product Name: quinoline-6-carboxaMide
• Synonyms: quinoline-6-carboxaMide;6-quinolinecarboxamide
• CAS NO: 5382-43-4
• Molecular Formula: C₁₀H₈N₂O
• Molecular Weight: 172.18332
• Mol File: 5382-43-4.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: quinoline-6-carboxaMide(CAS DataBase Reference)
• NIST Chemistry Reference: quinoline-6-carboxaMide(5382-43-4)
• EPA Substance Registry System: quinoline-6-carboxaMide(5382-43-4)

Safety Data

• Hazardous Substances Data: 5382-43-4(Hazardous Substances Data)

Usage

General Description

Quinoline-6-carboxamide, also known as quinaldinecarboxamide, is an organic compound with the chemical formula C10H8N2O. It is a derivative of quinoline and contains a carboxamide functional group. Quinoline-6-carboxamide is a white solid that is sparingly soluble in water and is commonly used as a building block in the synthesis of various pharmaceuticals and organic compounds. It has also been studied for its potential use as an anti-cancer agent and as a corrosion inhibitor. Additionally, this compound has been found to exhibit herbicidal activity and is used as an intermediate in the production of dyes and pigments.

Upstream product

• 23395-72-4 quinoline-6-carbonitrile 
• 13327-31-6 6-iodoquinoline 
• 64-18-6 formic acid 
• 5332-25-2 6-bromoquinoline 
• 201230-82-2 carbon monoxide 
• 38896-30-9 6-(methoxycarbonyl)quinoline 
• 150-13-0 4-amino-benzoic acid 
• 10349-57-2 Quinoline-6-carboxylic acid 
• 72369-87-0 quinoline-6-carbonyl chloride 
• 7664-93-9 sulfuric acid 

Downstream Products

• 99071-54-2 quinolin-6-ylmethanamine 
• 1459731-04-4 N-(2-(methylamino)-2-oxoethyl)-4-(3-(quinolin-6-ylmethyl)-3H-[1,2,3]triazolo[4,5-b]pyridin-5-yl)benzamide 
• 1459732-44-5 methyl 2,6-difluoro-4-(3-(quinolin-6-ylmethyl)-3H-imidazo[4,5-b]pyridin-5-yl)benzoate 
• 1459732-45-6 2,6-difluoro-4-(3-(quinolin-6-ylmethyl)-3H-imidazo[4,5-b]pyridin-5-yl)benzoic acid 
• 1350426-32-2 methyl 2-fluoro-4-(3-(quinolin-6-ylmethyl)-3H-[1,2,3]-triazolo[4,5-b]pyridin-5-yl)benzoate 
• 1350426-33-3 2-fluoro-4-(3-(quinolin-6-ylmethyl)-3H-[1,2,3]-triazolo[4,5-b]pyridin-5-yl)benzoic acid 
• 1350427-58-5 2,6-difluoro-4-(3-(quinolin-6-ylmethyl)-3H-[1,2,3]triazolo[4,5-b]pyridin-5-yl)benzoic acid 
• 1350427-57-4 methyl 2,6-difluoro-4-(3-(quinolin-6-ylmethyl)-3H-[1,2,3]-triazolo[4,5-b]pyridin-5-yl)benzoate 
• 1350426-28-6 4-(3-(quinolin-6-ylmethyl)-3H-[1,2,3]-triazolo[4,5-b]pyridin-5-yl)benzoic acid 
• 1350426-27-5 methyl 4-(3-(quinolin-6-ylmethyl)-3H-[1,2,3]-triazolo[4,5-b]pyridin-5-yl)benzoate 
• 1459732-54-7 4-(3-quinolin-6-ylmethyl-3H-imidazo[4,5-b]pyridin-5-yl)-2-trifluoromethyl-benzamide 
• 1459732-49-0 2-chloro-4-(3-(quinolin-6-ylmethyl)-3H-imidazo[4,5-b]pyridin-5-yl)benzamide 2,2,2-trifluoroacetate 
• 1459732-41-2 2-chloro-4-(3-(quinolin-6-ylmethyl)-3H-imidazo[4,5-b]pyridin-5-yl)benzamide hydrochloride 
• 1350428-31-7 2-chloro-4-(3-(quinolin-6-ylmethyl)-3H-imidazo[4,5-b]pyridin-5-yl)benzamide 

Relevant articles and documents

Pyridinium-2-carbaldoximes with quinolinium carboxamide moiety are simultaneous reactivators of acetylcholinesterase and butyrylcholinesterase inhibited by nerve agent surrogates

The pyridinium-2-carbaldoximes with quinolinium carboxamide moiety were designed and synthesised as cholinesterase reactivators. The prepared compounds showed intermediate-to-high inhibition of both cholinesterases when compared to standard oximes. Their reactivation ability was evaluated in?vitro on human recombinant acetylcholinesterase (hrAChE) and human recombinant butyrylcholinesterase (hrBChE) inhibited by nerve agent surrogates (NIMP, NEMP, and NEDPA) or paraoxon. In the reactivation screening, one compound was able to reactivate hrAChE inhibited by all used organophosphates and two novel compounds were able to reactivate NIMP/NEMP-hrBChE. The reactivation kinetics revealed compound 11 that proved to be excellent reactivator of paraoxon-hrAChE better to obidoxime and showed increased reactivation of NIMP/NEMP-hrBChE, although worse to obidoxime. The molecular interactions of studied reactivators were further identified by in silico calculations. Molecular modelling results revealed the importance of creation of the pre-reactivation complex that could lead to better reactivation of both cholinesterases together with reducing particular interactions for lower intrinsic inhibition by the oxime.

NOVEL 3,5-DISUBSTITUTED-3H-IMIDAZO[4,5-B]PYRIDINE AND 3,5- DISUBSTITUTED -3H-[1,2,3]TRIAZOLO[4,5-B] PYRIDINE COMPOUNDS AS MODULATORS OF C-MET PROTEIN, ETC

The present invention provides compounds useful as c-Met protein kinase modulators, methods of preparing them, pharmaceutical compositions containing them and methods of treatment, prevention and/or amelioration of c-Met kinase mediated disease or disorders with them.

NOVEL 3,5-DISUBSTITUED-3H-IMIDAZO[4,5-B]PYRIDINE AND 3,5- DISUBSTITUED -3H-[1,2,3]TRIAZOLO[4,5-B] PYRIDINE COMPOUNDS AS MODULATORS OF C-MET PROTEIN KINASES

The present invention provides compounds useful as C-met protein kinase modulators, methods of preparing them, pharmaceutical compositions containing them and methods of treatment, prevention and/or amelioration of C-met kinase mediated diseases or disorders with them.