2-benzoyl-3-isobutylidene-hexahydro-pyrrolo[1,2-a]pyrazine-1,4-dione

Base Information

• Chemical Name: 2-benzoyl-3-isobutylidene-hexahydro-pyrrolo[1,2-a]pyrazine-1,4-dione
• CAS No.: 51219-48-8
• Molecular Formula: C₁₈H₂₀N₂O₃
• Molecular Weight: 312.368
• Mol file: 51219-48-8.mol

Synonyms:2-benzoyl-3-isobutylidene-hexahydro-pyrrolo[1,2-a]pyrazine-1,4-dione

Chemical Property of 2-benzoyl-3-isobutylidene-hexahydro-pyrrolo[1,2-a]pyrazine-1,4-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 2-benzoyl-3-isobutylidene-hexahydro-pyrrolo[1,2-a]pyrazine-1,4-dione

There total 2 articles about 2-benzoyl-3-isobutylidene-hexahydro-pyrrolo[1,2-a]pyrazine-1,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

benzoyl chloride (98-88-4) + (S)-3-[(Z)-isobutylidene]hexahydropyrrolo[1,2-a]pyrazine-1,4-dione (114673-62-0) → 2-benzoyl-3-isobutylidene-hexahydro-pyrrolo[1,2-a]pyrazine-1,4-dione (51219-48-8)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 96h;

DOI:10.1021/jo0100897

Reference yield:

→ 2-benzoyl-3-isobutylidene-hexahydro-pyrrolo[1,2-a]pyrazine-1,4-dione (51219-48-8)

Guidance literature:

Reference yield: 95.0%

2-benzoyl-3-isobutylidene-hexahydro-pyrrolo[1,2-a]pyrazine-1,4-dione (51219-48-8) → C18H20N2O4 (167864-25-7)

Guidance literature:

With 2-methyl-1,2-epoxypropane; magnesium sulfate; In dichloromethane; acetone; at 20 ℃; for 12h;

DOI:10.1055/s-2003-36259

upstream raw materials:

benzoyl chloride

(S)-3-[(Z)-isobutylidene]hexahydropyrrolo[1,2-a]pyrazine-1,4-dione

Downstream raw materials:

C₁₈H₂₀N₂O₄

cyclo(L-Pro-L-Leu)