3-Isobutylhexahydropyrrolo[1,2-a]pyrazine-1,4-dione

Base Information

Chemical Name:3-Isobutylhexahydropyrrolo[1,2-a]pyrazine-1,4-dione
CAS No.:2873-36-1
Molecular Formula:C11H18 N2 O2
Molecular Weight:210.276
Hs Code.:2933990090
DSSTox Substance ID:DTXSID80951384
Nikkaji Number:J92.058D
Wikidata:Q72460568
Metabolomics Workbench ID:46467
Mol file:2873-36-1.mol

Synonyms:cyclo(Pro-Leu);cyclo(prolyl-leucyl);cyclo-(R-Pro-R-Leu);cyclo-(R-prolyl-R-leucyl)

Suppliers and Price of 3-Isobutylhexahydropyrrolo[1,2-a]pyrazine-1,4-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Cyclo(L-prolyl-L-leucyl)
25mg
$ 425.00

Medical Isotopes, Inc.
Cyclo(L-prolyl-L-leucyl)
10 mg
$ 650.00

Crysdot
(3S,8aS)-3-Isobutylhexahydropyrrolo[1,2-a]pyrazine-1,4-dione 95+%
1g
$ 324.00

Chemenu
(3S,8aS)-3-isobutylhexahydropyrrolo[1,2-a]pyrazine-1,4-dione 95%
1g
$ 303.00

Cayman Chemical
Cyclo(L-Leu-L-Pro) ≥95%
5mg
$ 99.00

Cayman Chemical
Cyclo(L-Leu-L-Pro) ≥95%
25mg
$ 347.00

Biosynth Carbosynth
Cyclo(L-prolyl-L-leucyl)
100 mg
$ 130.00

Biosynth Carbosynth
Cyclo(L-prolyl-L-leucyl)
50 mg
$ 80.00

Biosynth Carbosynth
Cyclo(L-prolyl-L-leucyl)
25 mg
$ 50.00

Biosynth Carbosynth
Cyclo(L-prolyl-L-leucyl)
500 mg
$ 300.00

Total 31 raw suppliers

Chemical Property of 3-Isobutylhexahydropyrrolo[1,2-a]pyrazine-1,4-dione

Chemical Property:

Vapor Pressure:1.62E-07mmHg at 25°C
Melting Point:163-165℃
Boiling Point:427.6°Cat760mmHg
PKA:13.27±0.40(Predicted)
Flash Point:212.4°C
PSA：49.41000
Density:1.14g/cm³
LogP:0.78860
Storage Temp.:-15°C
Solubility.:Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly)
XLogP3:1.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:210.136827821
Heavy Atom Count:15
Complexity:288

Purity/Quality:

97% ^*data from raw suppliers

Cyclo(L-prolyl-L-leucyl) ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)CC1C(=O)N2CCCC2C(=O)N1
Description Cyclo(L-Leu-L-Pro) is a diketopiperazine metabolite that has been isolated from various bacterial and fungal species including Streptomyces. It is active against twelve strains of vancomycin-resistant enterococci (VRE) with MIC values of 12.5 μg/ml for E. faecalis strains K-99-34, K-00-184, and K-00-221. It also inhibits growth of K562, HL-60, and U937 leukemia cells in a concentration-dependent manner when used at concentrations of 1-500 μg/ml. Cyclo(L-Leu-L-Pro) also has antifouling activity, inhibiting attachment of B. amphitrite larva with an EC50 value of 0.15 mM.
Uses Sorbicillin analog. A bioactive secondary metabolites from terrestrial Streptomyces species TN262.

Technology Process of 3-Isobutylhexahydropyrrolo[1,2-a]pyrazine-1,4-dione

There total 58 articles about 3-Isobutylhexahydropyrrolo[1,2-a]pyrazine-1,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 114673-62-0
(S)-3-[(Z)-isobutylidene]hexahydropyrrolo[1,2-a]pyrazine-1,4-dione

: 2873-36-1
cyclo(L-Pro-L-Leu)

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; for 17h; under 760 Torr; Ambient temperature;
DOI:10.1002/prac.19983400415