N₅,1-bis(4-aminophenyl)-N₃-(2,3-dimethylphenyl)-1H-pyrazole-3,5-dicarboxamide

Base Information

• Chemical Name: N₅,1-bis(4-aminophenyl)-N₃-(2,3-dimethylphenyl)-1H-pyrazole-3,5-dicarboxamide
• CAS No.: 1357616-67-1
• Molecular Formula: C₂₅H₂₄N₆O₂
• Molecular Weight: 440.505
• Mol file: 1357616-67-1.mol

Synonyms:N₅,1-bis(4-aminophenyl)-N₃-(2,3-dimethylphenyl)-1H-pyrazole-3,5-dicarboxamide

Chemical Property of N₅,1-bis(4-aminophenyl)-N₃-(2,3-dimethylphenyl)-1H-pyrazole-3,5-dicarboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N₅,1-bis(4-aminophenyl)-N₃-(2,3-dimethylphenyl)-1H-pyrazole-3,5-dicarboxamide

There total 7 articles about N₅,1-bis(4-aminophenyl)-N₃-(2,3-dimethylphenyl)-1H-pyrazole-3,5-dicarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

C35H40N6O6 (1357616-72-8) → N5,1-bis(4-aminophenyl)-N3-(2,3-dimethylphenyl)-1H-pyrazole-3,5-dicarboxamide (1357616-67-1)

Guidance literature:

C₃₅H₄₀N₆O₆; With hydrogenchloride; In water; ethyl acetate; at 20 ℃;

With ammonia;

DOI:10.1016/j.ejmech.2011.12.031

Reference yield:

N-(tert-butoxycarbonyl)-1,4-phenylenediamine (71026-66-9) → N5,1-bis(4-aminophenyl)-N3-(2,3-dimethylphenyl)-1H-pyrazole-3,5-dicarboxamide (1357616-67-1)

Guidance literature:

Multi-step reaction with 6 steps

1.1: hydrogenchloride; sodium nitrite / methanol; water

2.1: silver carbonate / 1,4-dioxane / 24 h / 80 °C

3.1: sodium hydroxide / methanol / 20 °C / Inert atmosphere

3.2: pH 4

4.1: tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

5.1: tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

6.1: hydrogenchloride / water; ethyl acetate / 20 °C

With hydrogenchloride; silver carbonate; sodium hydroxide; sodium nitrite; In tetrahydrofuran; 1,4-dioxane; methanol; water; ethyl acetate;

DOI:10.1016/j.ejmech.2011.12.031

Reference yield:

C30H33N7O6 → N5,1-bis(4-aminophenyl)-N3-(2,3-dimethylphenyl)-1H-pyrazole-3,5-dicarboxamide (1357616-67-1)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

2: hydrogenchloride / water; ethyl acetate / 20 °C

With hydrogenchloride; In tetrahydrofuran; water; ethyl acetate;

DOI:10.1016/j.ejmech.2011.12.031

upstream raw materials:

1-(4-((tert-butoxycarbonyl)amino)phenyl)-5-((4-((tert-butoxycarbonyl)amino)phenyl)carbamoyl)-1H-pyrazole-3-carboxylic acid

C₃₅H₄₀N₆O₆

tert-butyl (4-propiolamidophenyl)carbamate

methyl 1-(4-((tert-butoxycarbonyl)amino)phenyl)-5-((4-((tert-butoxycarbonyl)amino)phenyl)carbamoyl)-1H-pyrazole-3-carboxylate