4-(3-chloro-5-(1,3-dihydroxypropan-2-yl)pyridin-2-yl)-N-(4-trifluoromethylphenyl)-5,6-dihydropyridine-1(2H)-carboxamide

Base Information

Chemical Name:4-(3-chloro-5-(1,3-dihydroxypropan-2-yl)pyridin-2-yl)-N-(4-trifluoromethylphenyl)-5,6-dihydropyridine-1(2H)-carboxamide
CAS No.:1073616-38-2
Molecular Formula:C₂₁H₂₁ClF₃N₃O₃
Molecular Weight:455.864
Hs Code.:

Synonyms:4-(3-chloro-5-(1,3-dihydroxypropan-2-yl)pyridin-2-yl)-N-(4-trifluoromethylphenyl)-5,6-dihydropyridine-1(2H)-carboxamide

Suppliers and Price of 4-(3-chloro-5-(1,3-dihydroxypropan-2-yl)pyridin-2-yl)-N-(4-trifluoromethylphenyl)-5,6-dihydropyridine-1(2H)-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-(3-chloro-5-(1,3-dihydroxypropan-2-yl)pyridin-2-yl)-N-(4-trifluoromethylphenyl)-5,6-dihydropyridine-1(2H)-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-(3-chloro-5-(1,3-dihydroxypropan-2-yl)pyridin-2-yl)-N-(4-trifluoromethylphenyl)-5,6-dihydropyridine-1(2H)-carboxamide

There total 15 articles about 4-(3-chloro-5-(1,3-dihydroxypropan-2-yl)pyridin-2-yl)-N-(4-trifluoromethylphenyl)-5,6-dihydropyridine-1(2H)-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 455-14-1
4-trifluoromethylphenylamine

: 1073618-02-6
2-(5-chloro-6-(1,2,3,6-tetrahydropyridin-4-yl)pyridin-3-yl)propane-1,3-diol hydrochloride

: 1073616-38-2
4-(3-chloro-5-(1,3-dihydroxypropan-2-yl)pyridin-2-yl)-N-(4-trifluoromethylphenyl)-5,6-dihydropyridine-1(2H)-carboxamide

Guidance literature:: 4-trifluoromethylphenylamine; With pyridine; 4-Nitrophenyl chloroformate; In dichloromethane; at 0 - 25 ℃; for 2h;

2-(5-chloro-6-(1,2,3,6-tetrahydropyridin-4-yl)pyridin-3-yl)propane-1,3-diol hydrochloride; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 1h;

Reference yield:

: 41667-95-2
5,6-dichloronicotinic acid

: 1073616-38-2
4-(3-chloro-5-(1,3-dihydroxypropan-2-yl)pyridin-2-yl)-N-(4-trifluoromethylphenyl)-5,6-dihydropyridine-1(2H)-carboxamide

Guidance literature:: Multi-step reaction with 12 steps

1.1: thionyl chloride / 1,2-dichloro-ethane; N,N-dimethyl-formamide / 25 °C

1.2: 3 h / 75 °C

2.1: triethylamine / dichloromethane / 16 h / 0 - 25 °C

3.1: sodium tetrahydroborate / methanol / 0 - 25 °C

4.1: toluene-4-sulfonic acid / chlorobenzene / 140 °C

5.1: potassium osmate; potassium carbonate; 1,4-bis(9-O-dihydroquinidine)phthalazine; potassium hexacyanoferrate(III) / water; tert-butyl alcohol / 16 - 24 h / 0 - 25 °C

5.2: 0.5 h / 25 °C

6.1: 1H-imidazole / dichloromethane / 2.5 h / 0 - 25 °C

7.1: 2-iodoxybenzoic acid / tetrahydrofuran; dimethyl sulfoxide / 5 h / 25 °C

8.1: potassium tert-butylate / toluene / 1 h / 0 °C

8.2: 3 h / 0 °C

9.1: dimethylsulfide borane complex / tetrahydrofuran / 5 h / 0 - 25 °C

9.2: 2 h / 0 °C

10.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane; ethanol; water / 1.5 h / 25 - 60 °C

11.1: hydrogenchloride / 1,4-dioxane; methanol; dichloromethane / 2 h / 25 °C

12.1: pyridine; 4-Nitrophenyl chloroformate / dichloromethane / 2 h / 0 - 25 °C

12.2: 1 h / 0 °C

With pyridine; 1H-imidazole; hydrogenchloride; sodium tetrahydroborate; thionyl chloride; potassium osmate; dimethylsulfide borane complex; 2-iodoxybenzoic acid; potassium tert-butylate; potassium carbonate; toluene-4-sulfonic acid; 4-Nitrophenyl chloroformate; 1,4-bis(9-O-dihydroquinidine)phthalazine; triethylamine; potassium hexacyanoferrate(III); (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; water; dimethyl sulfoxide; 1,2-dichloro-ethane; N,N-dimethyl-formamide; chlorobenzene; toluene; tert-butyl alcohol;

Reference yield:

: 162327-73-3
5,6-dichloro-N-methoxy-N-methyl-3-pyridinecarboxamide

: 1073616-38-2
4-(3-chloro-5-(1,3-dihydroxypropan-2-yl)pyridin-2-yl)-N-(4-trifluoromethylphenyl)-5,6-dihydropyridine-1(2H)-carboxamide

Guidance literature:: Multi-step reaction with 11 steps

1.1: tetrahydrofuran / 1 h / 0 °C

1.2: 0 °C

2.1: sodium tetrahydroborate / methanol / 0 - 25 °C

3.1: toluene-4-sulfonic acid / chlorobenzene / 140 °C

4.1: potassium osmate; potassium carbonate; 1,4-bis(9-O-dihydroquinidine)phthalazine; potassium hexacyanoferrate(III) / water; tert-butyl alcohol / 16 - 24 h / 0 - 25 °C

4.2: 0.5 h / 25 °C

5.1: 1H-imidazole / dichloromethane / 2.5 h / 0 - 25 °C

6.1: 2-iodoxybenzoic acid / tetrahydrofuran; dimethyl sulfoxide / 5 h / 25 °C

7.1: potassium tert-butylate / toluene / 1 h / 0 °C

7.2: 3 h / 0 °C

8.1: dimethylsulfide borane complex / tetrahydrofuran / 5 h / 0 - 25 °C

8.2: 2 h / 0 °C

9.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane; ethanol; water / 1.5 h / 25 - 60 °C

10.1: hydrogenchloride / 1,4-dioxane; methanol; dichloromethane / 2 h / 25 °C

11.1: pyridine; 4-Nitrophenyl chloroformate / dichloromethane / 2 h / 0 - 25 °C

11.2: 1 h / 0 °C

With pyridine; 1H-imidazole; hydrogenchloride; sodium tetrahydroborate; potassium osmate; dimethylsulfide borane complex; 2-iodoxybenzoic acid; potassium tert-butylate; potassium carbonate; toluene-4-sulfonic acid; 4-Nitrophenyl chloroformate; 1,4-bis(9-O-dihydroquinidine)phthalazine; potassium hexacyanoferrate(III); (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; water; dimethyl sulfoxide; chlorobenzene; toluene; tert-butyl alcohol;