Ethyl 2-{4-[(1-{4-[4-amino-2-(2-methoxyethyl)-1H-imidazo[4,5-c]quinolin-1-yl]butyl}-3-{2-(piperidin-1-yl)ethyl}ureido)methyl]phenoxy}acetate

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Chemical Name:Ethyl 2-{4-[(1-{4-[4-amino-2-(2-methoxyethyl)-1H-imidazo[4,5-c]quinolin-1-yl]butyl}-3-{2-(piperidin-1-yl)ethyl}ureido)methyl]phenoxy}acetate
CAS No.:1310697-96-1
Molecular Formula:C₃₆H₄₉N₇O₅
Molecular Weight:659.829
Hs Code.:

Synonyms:Ethyl 2-{4-[(1-{4-[4-amino-2-(2-methoxyethyl)-1H-imidazo[4,5-c]quinolin-1-yl]butyl}-3-{2-(piperidin-1-yl)ethyl}ureido)methyl]phenoxy}acetate

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Chemical Property of Ethyl 2-{4-[(1-{4-[4-amino-2-(2-methoxyethyl)-1H-imidazo[4,5-c]quinolin-1-yl]butyl}-3-{2-(piperidin-1-yl)ethyl}ureido)methyl]phenoxy}acetate

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Technology Process of Ethyl 2-{4-[(1-{4-[4-amino-2-(2-methoxyethyl)-1H-imidazo[4,5-c]quinolin-1-yl]butyl}-3-{2-(piperidin-1-yl)ethyl}ureido)methyl]phenoxy}acetate

There total 3 articles about Ethyl 2-{4-[(1-{4-[4-amino-2-(2-methoxyethyl)-1H-imidazo[4,5-c]quinolin-1-yl]butyl}-3-{2-(piperidin-1-yl)ethyl}ureido)methyl]phenoxy}acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 27578-60-5
1-(2-aminoethyl)piperidine

: 1310697-97-2
C₂₈H₃₅N₅O₄

: 7693-46-1
4-Nitrophenyl chloroformate

: 1310697-96-1
Ethyl 2-{4-[(1-{4-[4-amino-2-(2-methoxyethyl)-1H-imidazo[4,5-c]quinolin-1-yl]butyl}-3-{2-(piperidin-1-yl)ethyl}ureido)methyl]phenoxy}acetate

Guidance literature:: C₂₈H₃₅N₅O₄; 4-Nitrophenyl chloroformate; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 0 ℃; for 0.5h;

1-(2-aminoethyl)piperidine; In tetrahydrofuran; dimethyl sulfoxide; at 20 ℃;

Reference yield:

: 51264-69-8
ethyl 2-(4-formylphenoxy)acetate

: 1310697-96-1
Ethyl 2-{4-[(1-{4-[4-amino-2-(2-methoxyethyl)-1H-imidazo[4,5-c]quinolin-1-yl]butyl}-3-{2-(piperidin-1-yl)ethyl}ureido)methyl]phenoxy}acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium cyanoborohydride; acetic acid / methanol / 0 - 20 °C

2.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.5 h / 0 °C

2.2: 20 °C

With sodium cyanoborohydride; acetic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol;

Reference yield:

: 22042-71-3
(4-formylphenoxy)acetic acid

: 1310697-96-1
Ethyl 2-{4-[(1-{4-[4-amino-2-(2-methoxyethyl)-1H-imidazo[4,5-c]quinolin-1-yl]butyl}-3-{2-(piperidin-1-yl)ethyl}ureido)methyl]phenoxy}acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sulfuric acid / 4 h / Reflux

2.1: sodium cyanoborohydride; acetic acid / methanol / 0 - 20 °C

3.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.5 h / 0 °C

3.2: 20 °C

With sulfuric acid; sodium cyanoborohydride; acetic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol;