7-[3-(Trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide

Base Information

Chemical Name:7-[3-(Trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide
CAS No.:115930-92-2
Molecular Formula:C14H9 F3 N4 O
Molecular Weight:306.24
Hs Code.:2933998090
European Community (EC) Number:670-988-1
DSSTox Substance ID:DTXSID30380620
Wikidata:Q82170948
ChEMBL ID:CHEMBL1383028
Mol file:115930-92-2.mol

Synonyms:115930-92-2;7-[3-(trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide;7-(3-(Trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;7-[3-(trifluoromethyl)phenyl]pyrazolo[1,5-a]-pyrimidine-3-carboxamide;7-[3-(Trifluoromethyl)phenylpyrazolo[1,5-a]-pyrimidine-3-carboxamide;Maybridge3_006293;MLS000861940;SCHEMBL8435070;CHEMBL1383028;DTXSID30380620;HMS1448O01;HMS2811L18;MFCD00276606;AKOS015912409;CCG-245133;IDI1_017680;SMR000460724;CS-0441444;FT-0621335;A803514;7-(3-(trifluoromethyl) phenyl)pyrazolo(1,5-a)pyrimidine-3-carboxamide;Pyrazolo[1,5-a]pyrimidine-3-carboxamide, 7-[3-(trifluoromethyl)phenyl]-;7-(alpha,alpha,alpha-trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXAMIDE,7-[3-(TRIFLUOROMETHYL)PHENYL]-

Suppliers and Price of 7-[3-(Trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
7-[3-(Trifluoromethyl)phenylpyrazolo[1,5-a]-pyrimidine-3-carboxamide
100mg
$ 75.00

Matrix Scientific
7-[3-(Trifluoromethyl)phenylpyrazolo[1,5-a]-pyrimidine-3-carboxamide
500mg
$ 35.00

Crysdot
7-(3-(Trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide 95+%
25g
$ 476.00

Chemenu
7-(3-(Trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide 95%
25g
$ 450.00

American Custom Chemicals Corporation
7-[3-(TRIFLUOROMETHYL)PHENYL]PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXAMIDE 95.00%
5G
$ 939.94

American Custom Chemicals Corporation
7-[3-(TRIFLUOROMETHYL)PHENYL]PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXAMIDE 95.00%
1G
$ 621.16

AK Scientific
7-[3-(Trifluoromethyl)phenylpyrazolo[1,5-a]-pyrimidine-3-carboxamide
500mg
$ 97.00

AHH
7-[3-(Trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide 97%
10g
$ 280.00

Total 18 raw suppliers

Chemical Property of 7-[3-(Trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide

Chemical Property:

Vapor Pressure:3.88E-07mmHg at 25°C
Boiling Point:°Cat760mmHg
Flash Point:°C
PSA：73.28000
Density:1.52g/cm³
LogP:3.21430
XLogP3:1.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:2
Exact Mass:306.07284541
Heavy Atom Count:22
Complexity:431

Purity/Quality:

97% ^*data from raw suppliers

7-[3-(Trifluoromethyl)phenylpyrazolo[1,5-a]-pyrimidine-3-carboxamide ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26-36/37/39

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=CC(=C1)C(F)(F)F)C2=CC=NC3=C(C=NN23)C(=O)N
Uses 7-[3-(Trifluoromethyl)phenylpyrazolo[1,5-a]-pyrimidine-3-carboxamide is an endosomal toll-like receptor (TLR8) inhibitor.

Technology Process of 7-[3-(Trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide

There total 6 articles about 7-[3-(Trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 72851-20-8
7-(α,α,α-trifluoro-m-tolyl)-pyrazolo[1,5-a]pyrimidine-3-carbonitrile

: 115930-92-2
7-(α,α,α-trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

Guidance literature:: With sulfuric acid;

Reference yield:

: 1026365-36-5
7-(3-Trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carbonyl chloride

: 115930-92-2
7-(α,α,α-trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

Guidance literature:: With ammonia; In tetrahydrofuran; dichloromethane;

Reference yield:

: 72851-46-8
7-(α,α,α-trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl ester

: 115930-92-2
7-(α,α,α-trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide; water / ethanol / 80 °C

2: thionyl chloride / Reflux

3: ammonia / tetrahydrofuran; dichloromethane

With thionyl chloride; ammonia; water; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane;