7-(α,α,α-trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl ester

Base Information

• Chemical Name: 7-(α,α,α-trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl ester
• CAS No.: 72851-46-8
• Molecular Formula: C₁₆H₁₂F₃N₃O₂
• Molecular Weight: 335.285

Synonyms:7-(α,α,α-trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl ester

Chemical Property of 7-(α,α,α-trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl ester

Chemical Property:

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Technology Process of 7-(α,α,α-trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl ester

There total 4 articles about 7-(α,α,α-trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

(E)-3-(dimethylamino)-1-(3-(trifluoromethyl)phenyl)prop-2-en-1-one (72851-19-5) + ethyl 5-amino-1H-pyrazole-4-carboxylate (1260243-04-6,6994-25-8) → 7-(α,α,α-trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl ester (72851-46-8)

Guidance literature:

With acetic acid; for 8h; Heating;

DOI:10.1016/0223-5234(94)90065-5

Reference yield:

(E)-3-(dimethylamino)-1-(3-(trifluoromethyl)phenyl)prop-2-en-1-one (72851-19-5) + 3-amino-4-pyrazolecarboxylic acid ethyl ester (6994-25-8,103259-35-4,19750-02-8) → 7-(α,α,α-trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl ester (72851-46-8)

Guidance literature:

In acetic acid;

Reference yield:

3-dimethylamino-3-(trifluoromethyl)acrylophenone (72851-19-5) + ethyl 5-amino-1H-pyrazole-4-carboxylate (1260243-04-6,6994-25-8) → 7-(α,α,α-trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl ester (72851-46-8)

Guidance literature:

With acetic acid; Reflux;

upstream raw materials:

(E)-3-(dimethylamino)-1-(3-(trifluoromethyl)phenyl)prop-2-en-1-one

ethyl 5-amino-1H-pyrazole-4-carboxylate

3'-(trifluoromethyl)acetophenone

3-amino-4-pyrazolecarboxylic acid ethyl ester

Downstream raw materials:

7-(3-(trifluoromethyl)phenyl)-3-pyrazolo<1,5-a>pyrimidine carboxylic acid

2-Methoxyethyl-7-(α,α,α-trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine-3-carboxylate

7-(α,α,α-trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

7-(3-Trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carbonyl chloride

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