t-3-t-butoxy-c-2-(2-hydroxypropyl)-c-3-phenyl-r-1-cyclopropanecarboxylic acid lactone

Base Information

Chemical Name:t-3-t-butoxy-c-2-(2-hydroxypropyl)-c-3-phenyl-r-1-cyclopropanecarboxylic acid lactone
CAS No.:92609-35-3
Molecular Formula:C₁₇H₂₂O₃
Molecular Weight:274.36
Hs Code.:

Synonyms:t-3-t-butoxy-c-2-(2-hydroxypropyl)-c-3-phenyl-r-1-cyclopropanecarboxylic acid lactone

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Chemical Property of t-3-t-butoxy-c-2-(2-hydroxypropyl)-c-3-phenyl-r-1-cyclopropanecarboxylic acid lactone

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Technology Process of t-3-t-butoxy-c-2-(2-hydroxypropyl)-c-3-phenyl-r-1-cyclopropanecarboxylic acid lactone

There total 7 articles about t-3-t-butoxy-c-2-(2-hydroxypropyl)-c-3-phenyl-r-1-cyclopropanecarboxylic acid lactone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 865-47-4
potassium tert-butylate

: 92609-32-0
1-chloro-c-2-(2-hydroxypropyl)-t-3-phenyl-r-1-cyclopropanecarboxylic acid

: 92609-35-3
t-3-t-butoxy-c-2-(2-hydroxypropyl)-c-3-phenyl-r-1-cyclopropanecarboxylic acid lactone

Guidance literature:: In tetrahydrofuran; at 0 ℃; for 1h;
DOI:10.1016/S0040-4020(01)88440-4

Reference yield:

: 13159-16-5
(E)-5-phenyl-4-penten-1-ol

: 92609-35-3
t-3-t-butoxy-c-2-(2-hydroxypropyl)-c-3-phenyl-r-1-cyclopropanecarboxylic acid lactone

Guidance literature:: Multi-step reaction with 4 steps

1: HCl

2: 50percent NaOH / benzyltriethylammonium chloride / CHCl₃ / 20 h

3: 1. BuLi 2. 2-chloro-1-methylpyridinium iodide / 1. -90 - -100 deg C, 1 hr

4: 54 percent / tetrahydrofuran / 1 h / 0 °C

With sodium hydroxide; n-butyllithium; 2-chloro-1-methyl-pyridinium iodide; hydrogenchloride; N-benzyl-N,N,N-triethylammonium chloride; In tetrahydrofuran; chloroform;
DOI:10.1016/S0040-4020(01)88440-4

Reference yield:

: 63082-55-3
diethyl (E)-cinnamyl malonate

: 92609-35-3
t-3-t-butoxy-c-2-(2-hydroxypropyl)-c-3-phenyl-r-1-cyclopropanecarboxylic acid lactone

Guidance literature:: Multi-step reaction with 7 steps

1: KOH / ethanol; H₂O / 4 h / Heating

2: 170 - 180 °C / 15 Torr

3: 89 percent / LiAlH₄ / tetrahydrofuran / 30 min at 0 deg C then 2 hrs at reflux

4: HCl

5: 50percent NaOH / benzyltriethylammonium chloride / CHCl₃ / 20 h

6: 1. BuLi 2. 2-chloro-1-methylpyridinium iodide / 1. -90 - -100 deg C, 1 hr

7: 54 percent / tetrahydrofuran / 1 h / 0 °C

With potassium hydroxide; sodium hydroxide; lithium aluminium tetrahydride; n-butyllithium; 2-chloro-1-methyl-pyridinium iodide; hydrogenchloride; N-benzyl-N,N,N-triethylammonium chloride; In tetrahydrofuran; ethanol; chloroform; water;
DOI:10.1016/S0040-4020(01)88440-4