Technology Process of 1-chloro-c-2-(2-hydroxypropyl)-t-3-phenyl-r-1-cyclopropanecarboxylic acid
There total 6 articles about 1-chloro-c-2-(2-hydroxypropyl)-t-3-phenyl-r-1-cyclopropanecarboxylic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: HCl
2: 50percent NaOH / benzyltriethylammonium chloride / CHCl3 / 20 h
3: 1. BuLi 2. 2-chloro-1-methylpyridinium iodide / 1. -90 - -100 deg C, 1 hr
With
sodium hydroxide; n-butyllithium; 2-chloro-1-methyl-pyridinium iodide;
hydrogenchloride; N-benzyl-N,N,N-triethylammonium chloride;
In
chloroform;
DOI:10.1016/S0040-4020(01)88440-4
- Guidance literature:
-
Multi-step reaction with 6 steps
1: KOH / ethanol; H2O / 4 h / Heating
2: 170 - 180 °C / 15 Torr
3: 89 percent / LiAlH4 / tetrahydrofuran / 30 min at 0 deg C then 2 hrs at reflux
4: HCl
5: 50percent NaOH / benzyltriethylammonium chloride / CHCl3 / 20 h
6: 1. BuLi 2. 2-chloro-1-methylpyridinium iodide / 1. -90 - -100 deg C, 1 hr
With
potassium hydroxide; sodium hydroxide; lithium aluminium tetrahydride; n-butyllithium; 2-chloro-1-methyl-pyridinium iodide;
hydrogenchloride; N-benzyl-N,N,N-triethylammonium chloride;
In
tetrahydrofuran; ethanol; chloroform; water;
DOI:10.1016/S0040-4020(01)88440-4
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 170 - 180 °C / 15 Torr
2: 89 percent / LiAlH4 / tetrahydrofuran / 30 min at 0 deg C then 2 hrs at reflux
3: HCl
4: 50percent NaOH / benzyltriethylammonium chloride / CHCl3 / 20 h
5: 1. BuLi 2. 2-chloro-1-methylpyridinium iodide / 1. -90 - -100 deg C, 1 hr
With
sodium hydroxide; lithium aluminium tetrahydride; n-butyllithium; 2-chloro-1-methyl-pyridinium iodide;
hydrogenchloride; N-benzyl-N,N,N-triethylammonium chloride;
In
tetrahydrofuran; chloroform;
DOI:10.1016/S0040-4020(01)88440-4