(S)-2-((2S,3S)-2-Benzyloxycarbonylamino-3-methyl-pentanoylamino)-succinic acid 4-tert-butyl ester

Base Information

• Chemical Name: (S)-2-((2S,3S)-2-Benzyloxycarbonylamino-3-methyl-pentanoylamino)-succinic acid 4-tert-butyl ester
• CAS No.: 119439-55-3
• Molecular Formula: C₂₂H₃₂N₂O₇
• Molecular Weight: 436.505
• Mol file: 119439-55-3.mol

Synonyms:(S)-2-((2S,3S)-2-Benzyloxycarbonylamino-3-methyl-pentanoylamino)-succinic acid 4-tert-butyl ester

Chemical Property of (S)-2-((2S,3S)-2-Benzyloxycarbonylamino-3-methyl-pentanoylamino)-succinic acid 4-tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-((2S,3S)-2-Benzyloxycarbonylamino-3-methyl-pentanoylamino)-succinic acid 4-tert-butyl ester

There total 2 articles about (S)-2-((2S,3S)-2-Benzyloxycarbonylamino-3-methyl-pentanoylamino)-succinic acid 4-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

α-carbobenzoxy-L-isoleucine p-nitrophenyl ester (2130-99-6) + L-Asp(t-Bu) (3057-74-7) → (S)-2-((2S,3S)-2-Benzyloxycarbonylamino-3-methyl-pentanoylamino)-succinic acid 4-tert-butyl ester (119439-55-3)

Guidance literature:

With sodium hydroxide; In N,N-dimethyl-formamide; at 20 ℃; for 15h;

Reference yield:

N-Z-L-isoleucine N-hydroxysuccinimide ester (3391-99-9) + L-Asp(t-Bu) (3057-74-7) → (S)-2-((2S,3S)-2-Benzyloxycarbonylamino-3-methyl-pentanoylamino)-succinic acid 4-tert-butyl ester (119439-55-3)

Guidance literature:

With triethylamine; In tetrahydrofuran; water; at 20 ℃; for 14h;

DOI:10.1021/jm058289o

Reference yield:

(S)-2-Amino-N-[(S)-1-((E)-2-methanesulfonyl-vinyl)-3-methyl-butyl]-propionamide; hydrochloride + (S)-2-((2S,3S)-2-Benzyloxycarbonylamino-3-methyl-pentanoylamino)-succinic acid 4-tert-butyl ester (119439-55-3) → (S)-3-((2S,3S)-2-Benzyloxycarbonylamino-3-methyl-pentanoylamino)-N-{(S)-1-[(S)-1-((E)-2-methanesulfonyl-vinyl)-3-methyl-butylcarbamoyl]-ethyl}-succinamic acid tert-butyl ester

Guidance literature:

(S)-2-((2S,3S)-2-Benzyloxycarbonylamino-3-methyl-pentanoylamino)-succinic acid 4-tert-butyl ester; With 4-methyl-morpholine; isobutyl chloroformate; In tetrahydrofuran; for 0.166667h; cooling;

(S)-2-Amino-N-[(S)-1-((E)-2-methanesulfonyl-vinyl)-3-methyl-butyl]-propionamide; hydrochloride; With 4-methyl-morpholine; In tetrahydrofuran; for 0.5h;

DOI:10.1021/jm058289o

upstream raw materials:

α-carbobenzoxy-L-isoleucine p-nitrophenyl ester

L-Asp(t-Bu)

N-Z-L-isoleucine N-hydroxysuccinimide ester

Downstream raw materials:

C₅₈H₉₇N₁₇O₁₆S

C₂₈H₄₃N₇O₁₀

C₄₉H₇₄N₁₄O₁₅